Asymptomatic Apical Periodontitis Lesions and Their Association With Systemic Inflammatory Burden: A Preliminary Prospective Clinical Study

Background: Apical periodontitis (AP) is an inflammatory disorder of the periapical tissues caused by the persistence of a microbial infection within the root canal system of the affected tooth. Clinically, it is symptomatic or asymptomatic depending on several factors such as the type of microorgan...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2023-10, Vol.15 (10), p.e46357-e46357
Main Authors: Sathyanarayanan, Kothandaraman, Ranjana, N I, Bhavana, Mohan, R, Megavarnan, Sankar, Aravinthan, Mirnalini, Selvakumar
Format: Article
Language:English
Subjects:
Allergy/Immunology
Asymptomatic
Cells
Chronic illnesses
Cytokines
Dentistry
Endodontics
Gum disease
Hematology
Infections
Inflammation
Leukocytes
Lymphocytes
Neutrophils
Standard deviation
Statistical significance
Systemic diseases
Variables
Variance analysis
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Summary:Background: Apical periodontitis (AP) is an inflammatory disorder of the periapical tissues caused by the persistence of a microbial infection within the root canal system of the affected tooth. Clinically, it is symptomatic or asymptomatic depending on several factors such as the type of microorganisms, bacterial load, immunological reaction, and local tissue mediators. Chronic or asymptomatic infections may initiate and modulate intravascular accumulation of inflammatory cells resulting in endothelial dysfunction which subsequently represents a possible systemic inflammatory burden.Aim: The present study aimed to evaluate the relationship between asymptomatic AP and systemic inflammatory burden by assessing the levels of chronic inflammatory cells.Methodology: A total of 25 patients diagnosed with asymptomatic AP who showed a negative response to the pulp sensitivity test with no history of any systemic diseases were included in this preliminary prospective observational study. Blood samples were collected at each phase of the study, and a complete hemogram was carried out. All hematological parameters were recorded before and after root canal therapy and they were analyzed for statistical significance at p
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.46357