Solitary Fibrous Tumor in the Retroperitoneal Space Arising from the Diaphragm

• Published in: In vivo (Athens) 2023-11, Vol.37 (6), p.2849-2853
• Main Authors: Seito, Toyoshi, Kaneko, Tomoyuki, Kawai, Taketo, Noda, Michio, Tokura, Yuumi, Yoshimura, Itsuki, Yasui, Mariko, Kikuchi, Yoshinao, Sasajima, Yuko, Nakagawa, Tohru
• Format: Article
• Language: English
• Subjects: Aged, 80 and over; Biomarkers, Tumor; Diaphragm - diagnostic imaging; Diaphragm - surgery; Female; Hemangiopericytoma; Humans; Retroperitoneal Space - pathology; Solitary Fibrous Tumors - diagnostic imaging; Solitary Fibrous Tumors - surgery; STAT6 Transcription Factor - genetics; STAT6 Transcription Factor - metabolism; Thorax
• ISSN: 0258-851X; 1791-7549
• DOI: 10.21873/invivo.13401

We present a case of solitary fibrous tumor, arising from the diaphragm in the retroperitoneal space, that was resected with robotic assistance. An 85-year-old female patient was referred to our hospital for evaluation of a suspected right renal tumor. Abdominal contrast-enhanced computed tomography revealed a tumor (maximum diameter, 36 mm) protruding from the superior pole of the right kidney. The patient was scheduled for robot-assisted, retroperitoneoscopic, partial nephrectomy based on a preoperative diagnosis of renal cell carcinoma. Intraoperative findings revealed that the tumor originated from the diaphragm and had no continuity with the renal parenchyma. Pathological examination revealed a solitary fibrous tumor. Solitary fibrous tumors are rare soft-tissue neoplasms with a distinct molecular feature of the fusion of nerve growth factor-inducible A gene-binding protein 2 with signal transducer and activator of transcription 6 gene (NAB2::STAT6). We believe that this is the first reported case of a solitary fibrous tumor arising from the diaphragm in the retroperitoneal space.