First-in-human in-vivo depiction of paraganglioma metabolism by hyperpolarised 13C-magnetic resonance

• Published in: BJR case reports 2023-11, Vol.9 (6), p.20220089
• Main Authors: Chowdhury, Rafat, Moorthy, Myuri, Smith, Lorna, Mueller, Christoph A, Gong, Fiona, Rogers, Harriet J, Papoutsaki, Marianthi-Vasiliki, Syer, Tom, Brembilla, Giorgio, Singh, Saurabh, Retter, Adam, Parry, Thomas, Clemente, Joey, Caselton, Lucy, Jeraj, Hassan, Bullock, Max, Mathew, Manju, Chung, Teng Teng, Akker, Scott, Chapple, Paul, Salsbury, Grace A, Bainbridge, Alan, Atkinson, David, Gadian, David G, Srirangalingam, Umasuthan, Punwani, Shonit
• Format: Article
• Language: English
• Subjects: Case Report
• ISSN: 2055-7159; 2055-7159
• DOI: 10.1259/bjrcr.20220089

Phaeochromocytomas (PCC) and paragangliomas (PGL), cumulatively referred to as PPGLs, are neuroendocrine tumours arising from neural crest-derived cells in the sympathetic and parasympathetic nervous systems. Predicting future tumour behaviour and the likelihood of metastatic disease remains problematic as genotype-phenotype correlations are limited, the disease has variable penetrance and, to date, no reliable molecular, cellular or histological markers have emerged. Tumour metabolism quantification can be considered as a method to delineating tumour aggressiveness by utilising hyperpolarised 13 C-MR (HP-MR). The technique may provide an opportunity to non-invasively characterise disease behaviour. Here, we present the first instance of the analysis of PPGL metabolism via HP-MR in a single case.Phaeochromocytomas (PCC) and paragangliomas (PGL), cumulatively referred to as PPGLs, are neuroendocrine tumours arising from neural crest-derived cells in the sympathetic and parasympathetic nervous systems. Predicting future tumour behaviour and the likelihood of metastatic disease remains problematic as genotype-phenotype correlations are limited, the disease has variable penetrance and, to date, no reliable molecular, cellular or histological markers have emerged. Tumour metabolism quantification can be considered as a method to delineating tumour aggressiveness by utilising hyperpolarised 13 C-MR (HP-MR). The technique may provide an opportunity to non-invasively characterise disease behaviour. Here, we present the first instance of the analysis of PPGL metabolism via HP-MR in a single case.