A suspected case of serotonin syndrome induced by palonosetron and ramosetron administration

Serotonin syndrome occurs when serotonin (5-hydroxytryptamine, 5-HT) levels increase and is accompanied by symptoms of mental status chang-es, neuromuscular abnormalities, and autonomic hyperactivity. Sero-tonin receptor 3 antagonists, such as palonosetron or ramosetron, are commonly used for their...

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Published in:Journal of exercise rehabilitation 2023-10, Vol.19 (5), p.309-312
Main Authors: Lee, Yo-Seob, Yi, Jae-Woo
Format: Article
Language:English
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Summary:Serotonin syndrome occurs when serotonin (5-hydroxytryptamine, 5-HT) levels increase and is accompanied by symptoms of mental status chang-es, neuromuscular abnormalities, and autonomic hyperactivity. Sero-tonin receptor 3 antagonists, such as palonosetron or ramosetron, are commonly used for their antiemetic effects during general anesthesia. However, overdosage of these drugs carries a risk of serotonergic tox-icity as they increase serum serotonin levels due to inhibition of sero-tonin reuptake. Serotonin syndrome caused by 5-HT3 antagonists is thought to be caused by the synergistic effects of high doses of seroto-nergic drugs or the combination of two or more serotonergic drugs with different mechanisms of action. The incidence of serotonin syndrome is unknown because it is a rare condition that cannot be selected for in randomized clinical trials. Therefore, physicians must focus on the clini-cal manifestations of the syndrome and manage patients before the condition becomes life-threatening.
ISSN:2288-176X
2288-1778
DOI:10.12965/jer.2346432.216