The altered sputum microbiome profile in patients with moderate and severe COPD compared to the healthy group in the Indian population [version 3; peer review: 1 approved, 1 not approved]

Background: Microbial culture-independent sequencing techniques have advanced our understanding of host-microbiome interactions in health and disease. The purpose of this study was to explore the dysbiosis of airway microbiota in patients with moderate or severe chronic obstructive pulmonary disease...

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Bibliographic Details
Published in:F1000 research 2023, Vol.12, p.528
Main Authors: Hazra, Druti, SM, Fayaz, Chawla, Kiran, Sintchenko, Vitali, Martinez, Elena, Magazine, Rahul, Siddalingaiah, Nayana
Format: Article
Language:English
Subjects:
Airway management
Chronic obstructive pulmonary disease
Consent
Discriminant analysis
Dysbacteriosis
Dyspnea
Gender
Hospitals
Immune response
Lung diseases
Microbiomes
Microbiota
Obstructive lung disease
Pathogens
Population
Prevotella
rRNA 16S
Sputum
Streptococcus
Streptococcus infections
Taxonomy
Variance analysis
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Summary:Background: Microbial culture-independent sequencing techniques have advanced our understanding of host-microbiome interactions in health and disease. The purpose of this study was to explore the dysbiosis of airway microbiota in patients with moderate or severe chronic obstructive pulmonary disease (COPD) and compare them with healthy controls. Methods: The COPD patients were investigated for disease severity based on airflow limitations and divided into moderate (50%≤FEV1
ISSN:2046-1402
2046-1402
DOI:10.12688/f1000research.132220.3