Cardiotrophin-1 in Asymptomatic Hypertensive Patients With Mild Diastolic Dysfunction: Potential Prognostic Value in Early Stages of Hypertensive Heart Disease

Background: Regardless of the advancements in modern technology and treatment options, heart failure (HF) exhibits impervious mortality and morbidity rates. Arterial hypertension poses one of the greatest risks for developing HF, yet the exact pathophysiological path and changes that lead from isola...

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Published in:Curēus (Palo Alto, CA) CA), 2023-10, Vol.15 (10), p.e46516-e46516
Main Authors: Vlahodimitris, Ioannis, Karangelis, Dimos, Moschaki, Maria, Moyssakis, Ioannis, Christodoulou, Konstantinos C, Perrea, Despoina N, Mourouzis, Iordanis, Papadogiannis, Dimitrios
Format: Article
Language:English
Subjects:
Antihypertensives
Asymptomatic
Biomarkers
Blood pressure
Cardiology
Cardiomyocytes
Cardiovascular disease
Doppler effect
Enzymes
Heart
Hypertension
Medical prognosis
Patients
Sample size
Statistical analysis
Vein & artery diseases
Velocity
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Summary:Background: Regardless of the advancements in modern technology and treatment options, heart failure (HF) exhibits impervious mortality and morbidity rates. Arterial hypertension poses one of the greatest risks for developing HF, yet the exact pathophysiological path and changes that lead from isolated hypertension to HF are still unclear. Cardiotrophin-1 (CT-1) serves as a promising prognostic biomarker for the onset of HF in hypertensive patients. The aim of this study was to investigate whether CT-1 levels are elevated in a selected group of asymptomatic hypertensive patients.Methods: In a selected cohort of 40 asymptomatic patients with early diastolic dysfunction (grade I), without any signs of increased filling pressures in the left ventricle, as well as 20 healthy individuals, the levels of CT-1 brain natriuretic peptide (BNP) along with various echocardiographic parameters were evaluated.Results: The mean age of the hypertensive patients was 56 ± 5 years and 52± 3.5 years for the normotensive controls. The hypertensive group exhibited higher levels of CT-1, which was not affected by left ventricular hypertrophy. Notably, in patients with normal E/E′ < 8 (n = 30), CT-1 levels were 1165 ± 471 pg/ml compared to 2069 ± 576 pg/ml in patients with marginal E/E′ > 8 and
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.46516