Continuous glucose monitoring-derived time in range and CV are associated with altered tissue characteristics of the carotid artery wall in people with type 2 diabetes

• Published in: Diabetologia 2023-12, Vol.66 (12), p.2356-2367
• Main Authors: Mita, Tomoya, Katakami, Naoto, Okada, Yosuke, Yoshii, Hidenori, Osonoi, Takeshi, Nishida, Keiko, Shiraiwa, Toshihiko, Kurozumi, Akira, Taya, Naohiro, Wakasugi, Satomi, Sato, Fumiya, Ishii, Ryota, Gosho, Masahiko, Shimomura, Iichiro, Watada, Hirotaka
• Format: Article
• Language: English
• Subjects: Arteriosclerosis; Atherosclerosis; Blood Glucose; Blood Glucose Self-Monitoring; Cardiovascular diseases; Carotid arteries; Carotid Arteries - diagnostic imaging; Carotid artery; Carotid Artery, Common - diagnostic imaging; Carotid Intima-Media Thickness; Clinical trials; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - drug therapy; Glucose monitoring; Human Physiology; Humans; Internal Medicine; Medicine; Medicine & Public Health; Metabolic Diseases; Prospective Studies; Regression analysis; Risk factors; Veins & arteries
• ISSN: 0012-186X; 1432-0428; 1432-0428
• DOI: 10.1007/s00125-023-06013-3

Aims/hypothesis Previous studies have suggested that glucose variability may accelerate atherosclerosis progression in people with type 2 diabetes. Current guidelines recommend assessing glycaemic control using continuous glucose monitoring (CGM), which provides a comprehensive glycaemic profile to supplement HbA 1c measurement. However, the association between CGM-derived metrics and atherosclerosis progression is not entirely clear. Methods This exploratory study used baseline data and data obtained after 104 weeks from an ongoing prospective, multicentre, observational study. Six hundred study participants with type 2 diabetes and no apparent history of symptomatic cardiovascular disease underwent CGM and ultrasonographic atherosclerosis measurements of the carotid arteries, including the intima–media thickness (IMT) and grey-scale median (GSM), at baseline and 104 weeks. Non-invasive ultrasonic tissue characterisation of the carotid artery wall or plaque using the GSM reflects vascular composition. Multivariate regression models were used to analyse the association between CGM-derived indices, mainly time in range (TIR) and CV, and changes in carotid atherosclerosis index values. Results Over the 104-week study period, there were modest increases in mean IMT (from 0.759±0.153 to 0.773±0.152 mm, p