30 Central Regulation of Kndy Neurons During Undernutrition in Sheep

Abstract Adequate energy intake is essential for reproduction. While we have known for decades that feed restriction inhibits gonadotropin-releasing hormone/luteinizing hormone (GnRH/LH) secretion, the central mechanisms that govern this reduction during undernutrition remain to be fully elucidated....

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Bibliographic Details
Published in:Journal of animal science 2023-11, Vol.101 (Supplement_3), p.230-231
Main Author: Nestor, Casey
Format: Article
Language:English
Subjects:
Dynorphin
Energy intake
Gonadotropin-releasing hormone
Gonadotropins
Kiss1 protein
Luteinizing hormone
Malnutrition
Neurokinin
Neurokinin B
Neurons
Pituitary (anterior)
Secretion
Undernutrition
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Summary:Abstract Adequate energy intake is essential for reproduction. While we have known for decades that feed restriction inhibits gonadotropin-releasing hormone/luteinizing hormone (GnRH/LH) secretion, the central mechanisms that govern this reduction during undernutrition remain to be fully elucidated. The past few years, we have focused on examining central mechanisms whereby chronic feed restriction in young sheep results in the inhibition of LH secretion. This presentation will focus on our current understanding of how feed restriction impacts kisspeptin/neurokinin B/dynorphin (KNDy) neurons in young sheep and will give a glimpse into our next few years as we examine how input to KNDy neurons could play a key role in regulating reproduction during undernutrition.
ISSN:0021-8812
1525-3163
DOI:10.1093/jas/skad281.279