Are unrefreshing naps associated with nocturnal sleep architecture specificities in idiopathic hypersomnia?

• Published in: Sleep (New York, N.Y.) N.Y.), 2023-11, Vol.46 (11), p.1
• Main Authors: Mombelli, Samantha, Deshaies-Rugama, Anne-Sophie, Blais, Hélène, Sekerovic, Zoran, Thompson, Cynthia, Desautels, Alex, Montplaisir, Jacques, Nigam, Milan, Carrier, Julie, Gosselin, Nadia
• Format: Article
• Language: English
• Subjects: Analysis; Disorders of Excessive Somnolence - complications; Disorders of Excessive Somnolence - diagnosis; Humans; Hypersomnia; Idiopathic Hypersomnia; Medical research; Medicine, Experimental; Narcolepsy; Polysomnography; Questionnaires; REM sleep; Sleep; Sleep - physiology; Sleep disorders; Sleep, Health, and Disease
• ISSN: 0161-8105; 1550-9109
• DOI: 10.1093/sleep/zsad175

Abstract Study Objectives Unrefreshing naps are supportive clinical features of idiopathic hypersomnia (IH) and are reported by more than 50% of IH patients. They are, however, not mandatory for the diagnosis, and their pathophysiological nature is not understood. This study aimed at verifying whether IH patients with and without unrefreshing naps constitute two subtypes of IH based on their demographic/clinical characteristics, and sleep architecture. Methods One hundred twelve IH patients underwent a polysomnography (PSG) followed by a multiple sleep latency test (MSLT). They completed questionnaires on excessive daytime sleepiness, mood, and sleep quality. They were met by sleep medicine physicians who conducted a semi-structured clinical interview and questioned them on refreshing aspects of their naps. Patients who reported unrefreshing naps were compared to patients reporting refreshing naps on questionnaires, MSLT and PSG variables, with age as a covariable. As sensitivity analyses, we performed the same comparisons in participants presenting objective markers of IH and those diagnosed with IH based only on clinical judgment (subjective IH), separately. Results In the whole sample, 61% of patients reported unrefreshing naps. These participants had less awakenings, a lower percentage of N1 sleep, less sleep stage transitions, and a higher percentage of REM sleep on the nighttime PSG compared to the refreshing naps subgroup. When subjective and objective IH patients were tested separately, more group differences were observed on PSG for subjective IH patients. Conclusions Patients with unrefreshing naps have less fragmented sleep compared to those with refreshing naps. Future studies should investigate whether this group difference indicates a weaker arousal drive. Graphical Abstract