Impact of protein deficient diet on the pharmacokinetics of glibenclamide in a model of malnutrition in rats

Purpose The present investigation deals with the impact of protein energy malnourished condition on the pharmacokinetic profile of glibenclamide. Protein energy malnourished condition leads to malnutrition related diabetes mellitus (MRDM), Fibrocalculus pancreatic diabetes mellitus (FCPD) or Lean bo...

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Bibliographic Details
Published in:Journal of diabetes and metabolic disorders 2023-09, Vol.22 (2), p.1531-1536
Main Authors: Tembhurne, Sachin, Palkar, Preetam, Kolhe, Swati, Gandhi, Santosh
Format: Article
Language:English
Subjects:
Albumin
Animal experimentation
Blood sugar
Body weight
Diabetes
Diet
Endocrinology
Glibenclamide
Hemoglobin
Malnutrition
Medicine
Medicine & Public Health
Metabolic Diseases
Prediabetic state
Research Article
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Summary:Purpose The present investigation deals with the impact of protein energy malnourished condition on the pharmacokinetic profile of glibenclamide. Protein energy malnourished condition leads to malnutrition related diabetes mellitus (MRDM), Fibrocalculus pancreatic diabetes mellitus (FCPD) or Lean body mass diabetes mellitus (LBMDM). Method In the present study, malnutrition was developed in female wistar rats using a modified protein deficient diet (0.5%). The experiment was performed on 12 animals, each group containing 6 female wistar rats. The control group animals were fed with standard pellet diet (AIN 93 G diet) while group 2 received the low protein diet (0.5%) for 75 days. Glibenclamide (Gli) suspension (30 mg/kg) was administered orally to these rats on 75 days and kinetic parameters were evaluated by HPLC analysis.The pharmacokinetic interpretation done by pksolver software version 2.0, statistical comparison done by applying student T test. Results The results of body weight and hematological parameters indicated a significant decreased in the body weight in protein deficit rats to 124.1 ± 6.2 g compared to 235.5 ± 8.4 g (p 
ISSN:2251-6581
2251-6581
DOI:10.1007/s40200-023-01282-6