A realistic approach to evaluating the effect of baseline lipid profile in postcoronary artery bypass grafting surgery

BackgroundThere are still many uncertainties in the association between lipid profile and postcoronary artery bypass grafting (CABG) outcomes. Although simplifying the association to linear equations makes it understandable but cannot explain many findings.HypothesisThere is a nonlinear associatin b...

Full description

Saved in:
Bibliographic Details
Published in:Clinical cardiology (Mahwah, N.J.) N.J.), 2023-11, Vol.46 (11), p.1408-1417
Main Authors: Sheikhy, Ali, Fallahzadeh, Aida, Sadeghian, Saeed, Pashang, Mina, Karimi, Abbas Ali, Bagheri, Jamshid, Ahmadi‐Tafti, Hossein, Hosseini, Kaveh
Format: Article
Language:English
Subjects:
Atherosclerosis
Cardiovascular disease
Cholesterol
Clinical Investigations
Coronary vessels
Diabetes
Ejection fraction
High density lipoprotein
Hypertension
Lipids
Lipoproteins
Metabolic disorders
Mortality
Variables
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:BackgroundThere are still many uncertainties in the association between lipid profile and postcoronary artery bypass grafting (CABG) outcomes. Although simplifying the association to linear equations makes it understandable but cannot explain many findings.HypothesisThere is a nonlinear associatin between lipid profile indices and adverse outcomes after CABG.MethodsA total of 17 555 patients who underwent isolated CABG between 2005 and 2016 were evaluated. During the median follow-up of 75.24 months, the Restricted Cubic Splines (RCS) estimated from the Cox regression model adjusted for all possible confounders was applied to show a nonlinear relationship of lipid profile contents with the “ln hazard ratio” of mortality and major cerebro-cardiac events (MACCE).ResultsThe relationship between LDL-C and HDL-C with all-cause mortality was nonlinear (nonlinear p were .004 and  114) and those in the lowest HDL-C level (Q1, HDL-C 
ISSN:0160-9289
1932-8737
DOI:10.1002/clc.24132