Modulators reducing the efficiency of oxidative ATP synthesis in mitochondria: protonophore uncouplers, cyclic redox agents, and decouplers

This work considers the main indicators of the oxidative phosphorylation efficiency in mitochondria: the ADP/O and H + /O ratios. Three groups of modulators that reduce the efficiency of oxidative phosphorylation are compared: protonophore uncouplers, cyclic redox compounds, and decouplers. It is no...

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Bibliographic Details
Published in:Biophysical reviews 2023-10, Vol.15 (5), p.851-857
Main Authors: Samartsev, Victor N., Semenova, Alena A., Belosludtsev, Konstantin N., Dubinin, Mikhail V.
Format: Article
Language:English
Subjects:
Biochemistry
Biological and Medical Physics
Biological Techniques
Biomedical and Life Sciences
Biophysics
Carbohydrate metabolism
Carbohydrates
Cell Biology
Efficiency
Hepatocytes
Life Sciences
Lipid metabolism
Lipids
Membrane Biology
Mitochondria
Modulators
Nanotechnology
Oxidative phosphorylation
Pharmacology
Phosphorylation
Review
Uncouplers
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Summary:This work considers the main indicators of the oxidative phosphorylation efficiency in mitochondria: the ADP/O and H + /O ratios. Three groups of modulators that reduce the efficiency of oxidative phosphorylation are compared: protonophore uncouplers, cyclic redox compounds, and decouplers. It is noted that some of them are considered effective therapeutic agents. The paper analyzes the authors’ original data on the mechanism of action of natural decouplers, represented by long-chain α,ω-dioic acids, as antioxidants. In conclusion, we discuss the hypothesis of their participation in the rescue of hepatocytes in various disorders of carbohydrate and lipid metabolism.
ISSN:1867-2450
1867-2469
DOI:10.1007/s12551-023-01160-8