Topical calcineurin inhibitors for atopic dermatitis

Clinical questionWhat are the risks and benefits of using topical calcineurin inhibitors for atopic dermatitis?Bottom lineFor improvement of atopic dermatitis, 0.1% tacrolimus ointment is at least equivalent to moderate-potency topical corticosteroids. Use of 1% pimecrolimus cream is better than pla...

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Bibliographic Details
Published in:Canadian family physician 2023-11, Vol.69 (11), p.773-774
Main Authors: Braschi, Émélie, Moe, Samantha S.
Format: Article
Language:English
Subjects:
Clinical outcomes
Eczema
Inhibitor drugs
Side effects
Steroids
Tools for Practice
Topical medication
Online Access:Get full text
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Summary:Clinical questionWhat are the risks and benefits of using topical calcineurin inhibitors for atopic dermatitis?Bottom lineFor improvement of atopic dermatitis, 0.1% tacrolimus ointment is at least equivalent to moderate-potency topical corticosteroids. Use of 1% pimecrolimus cream is better than placebo but is likely inferior to 0.1% tacrolimus ointment and moderate-potency corticosteroids. Burning skin sensation is common with early use (30% to 50% of users) but tapers off for most (
ISSN:0008-350X
1715-5258
DOI:10.46747/cfp.6911773