Endothelial cells differentiated from patient dermal fibroblast-derived induced pluripotent stem cells resemble vascular malformations of port-wine birthmark

Lesional induced pluripotent stem cell-derived endothelial cells can resemble pathological vascular phenotypes of port-wine birthmark (PWB). Our data demonstrate that multiple pathways, including Hippo and Wnt, NFκB, TNF, MAPK and cholesterol metabolism, are dysregulated. These data suggest new ther...

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Bibliographic Details
Published in:British journal of dermatology (1951) 2023-11, Vol.189 (6), p.780-783
Main Authors: Nguyen, Vi, Gao, Chao, Hochman, Marcelo L, Kravitz, Jacob, Chen, Elliott H, Friedman, Harold I, Wenceslau, Camilla F, Chen, Dongbao, Wang, Yunguan, Nelson, J Stuart, Jegga, Anil G, Tan, Wenbin
Format: Article
Language:English
Subjects:
Cell Differentiation
Endothelial Cells
Humans
Induced Pluripotent Stem Cells
Port-Wine Stain
Research Letter
Vascular Malformations
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Summary:Lesional induced pluripotent stem cell-derived endothelial cells can resemble pathological vascular phenotypes of port-wine birthmark (PWB). Our data demonstrate that multiple pathways, including Hippo and Wnt, NFκB, TNF, MAPK and cholesterol metabolism, are dysregulated. These data suggest new therapeutics can be developed to target such dysregulated pathways in the treatment of PWB.
ISSN:0007-0963
1365-2133
1365-2133
DOI:10.1093/bjd/ljad330