Sensory Modulation Disorder and its Neural Circuitry in Adults with ADHD: A Pilot Study

• Published in: Brain imaging and behavior 2021-04, Vol.15 (2), p.930-940
• Main Authors: Adra, Noor, Cao, Aihua, Makris, Nikos, Valera, Eve M.
• Format: Article
• Language: English
• Subjects: Adult; Adults; Anxiety; Attention Deficit Disorder with Hyperactivity - diagnostic imaging; Attention deficit hyperactivity disorder; Biomedical and Life Sciences; Biomedicine; Brain; Child; Circuits; Diencephalon; Humans; Hyperactivity; Information processing; Magnetic Resonance Imaging; Modulation; Neostriatum; Neural networks; Neuroimaging; Neuropsychology; Neuroradiology; Neurosciences; Original Research; Pilot Projects; Psychiatry; Reproducibility of Results; Sensory integration; Sensory integration disorders; Sensory perception; Social Behavior
• ISSN: 1931-7557; 1931-7565
• DOI: 10.1007/s11682-020-00302-w

Compared to healthy controls (HCs), individuals with attention-deficit/hyperactivity disorder (ADHD) exhibit more symptoms of sensory processing disorder (SPD), which is associated with difficulties in educational and social activities. Most studies examining comorbid SPD-ADHD have been conducted with children and have not explored relations to brain volumes. In this pilot study, we assessed a subtype of SPD, sensory modulation disorder (SMD), and its relation to select brain volumes in adults with ADHD. We administered part of the Sensory Processing 3-Dimensions Scale (SP3D) to assess subtypes of SMD and collected structural imaging scans from 25 adults with ADHD and 29 healthy controls (HCs). Relative to HCs, subjects with ADHD scored higher on sensory craving (SC) and sensory under-responsivity (SUR) subscales. Although sensory over-responsivity (SOR) was marginally higher, this was no longer true when accounting for co-occurring anxiety. In individuals with ADHD, both SC and SUR were positively associated with amygdalar volume, SUR was also positively associated with striatal volume, whereas SOR was negatively associated with posterior ventral diencephalon volume. These preliminary findings suggest that SC and SUR may be characteristic of ADHD while SOR may be driven by co-occurring anxiety. Because different modalities were associated with different brain volumes, our findings also suggest that the modalities may involve unique neural circuits, but with a partial overlap between SC and SUR. These pilot data provide support for conducting studies examining SMD in larger samples of adults with ADHD to determine reproducibility, applicability and implications of these findings.