A novel necroptosis signature for predicting survival in lung adenocarcinoma

To explore the necroptosis-related genes (NRGs) signature and its predictive values in lung adenocarcinoma (LUAD). The training cohort consisted of tumor samples from The Cancer Genome Atlas, and the validation set comprised data from the Gene Expression Omnibus. Univariate and multivariate Cox regr...

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Bibliographic Details
Published in:BMC medical genomics 2023-11, Vol.16 (1), p.305
Main Authors: Zang, Kui, Wang, Min, Zhu, Xingxing, Yao, Bin, Huang, Ying
Format: Article
Language:English
Subjects:
Adenocarcinoma
Adenocarcinoma of Lung - genetics
Analysis
Apoptosis
Cancer therapies
Cell death
China
Correlation analysis
Diagnosis
Evaluation
Gender
Gene expression
Genetic aspects
Genomes
Humans
Immune checkpoint
Immune Checkpoint Proteins
Kinases
Lung cancer
Lung Neoplasms - genetics
Medical prognosis
Mortality
Multivariate Analysis
Mutation
Necroptosis
Necroptosis - genetics
PD-L1 protein
Prognosis
Regression analysis
Risk groups
Survival
Therapeutic targets
Tumors
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Summary:To explore the necroptosis-related genes (NRGs) signature and its predictive values in lung adenocarcinoma (LUAD). The training cohort consisted of tumor samples from The Cancer Genome Atlas, and the validation set comprised data from the Gene Expression Omnibus. Univariate and multivariate Cox regression analyses were applied to identify the prognostic NRG signature as an independent molecular indicator. Correlation analysis was used for the association assessment between the NRG signature and immune checkpoint molecules. NRGs involved in necroptosis and immune NOD-like receptor signaling. The NRG signature based on eight NRGs can divide tumors into high-risk and low-risk groups, which was significantly associated with worse survival. Multivariate Cox regression analysis showed that this NRG signature remained an independent prognostic indicator. Stratification analyses demonstrated that this NRG signature was still effective for predicting survival in each stratum of age, gender, and tumor stage. The ROC curve showed a good predictive ability using the NRG signature in the validation cohort (AUC = 0.81). The NRG signature was related to immune checkpoint molecules PD - 1, PD-L1, and PD-L2. The NRG signature could be a novel predictor of the prognosis and may become a potential therapeutic target in LUAD.
ISSN:1755-8794
1755-8794
DOI:10.1186/s12920-023-01748-9