Structure-activity relationships andz interindividual variability of drug responses: pharmacogenomics with antimicrobial drugs as a paradigm

Adverse drug reactions represent a major health burden because they cause notable patient morbidity and mortality. From this viewpoint, several strategies have been developed to prevent or reduce adverse drug reactions. One such strategy is the use of pharmacogenomics. Interindividual variability in...

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Published in:Journal of international medical research 2023-11, Vol.51 (11), p.3000605231214065-3000605231214065
Main Authors: Thabet, Romany H, Alshar, Bayan Osama Shehadeh, Alabdallah, Doaa Habes Saleh, Alhmoud, Nour Alhuda Zaid Ahmad, Alslameen, Sondos Taher Abdalsalam, Thabet, Youssef Romany Helmy
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container_issue 11
container_start_page 3000605231214065
container_title Journal of international medical research
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creator Thabet, Romany H
Alshar, Bayan Osama Shehadeh
Alabdallah, Doaa Habes Saleh
Alhmoud, Nour Alhuda Zaid Ahmad
Alslameen, Sondos Taher Abdalsalam
Thabet, Youssef Romany Helmy
description Adverse drug reactions represent a major health burden because they cause notable patient morbidity and mortality. From this viewpoint, several strategies have been developed to prevent or reduce adverse drug reactions. One such strategy is the use of pharmacogenomics. Interindividual variability in drug response and adverse effects is mainly attributable to genetic variation in enzymes such as sulfotransferases and cytochrome P450s. The current narrative review discusses the relationship between the structure and activity of drugs. Specifically, the activity of drugs can be increased and/or their adverse effects can be reduced by altering specific positions in their structures.
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title Structure-activity relationships andz interindividual variability of drug responses: pharmacogenomics with antimicrobial drugs as a paradigm
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