Similarities in the induction of the intracellular pathogen response in Caenorhabditis elegans and the type I interferon response in mammals

Although the type-I interferon (IFN-I) response is considered vertebrate-specific, recent findings about the Intracellular Pathogen Response (IPR) in nematode Caenorhabditis elegans indicate that there are similarities between these two transcriptional immunological programs. The IPR is induced duri...

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Bibliographic Details
Published in:BioEssays 2023-11, Vol.45 (11), p.e2300097-e2300097
Main Authors: Lažetić, Vladimir, Batachari, Lakshmi E, Russell, Alistair B, Troemel, Emily R
Format: Article
Language:English
Subjects:
Animals
Caenorhabditis elegans
Caenorhabditis elegans - metabolism
Caenorhabditis elegans Proteins - metabolism
Defense programs
Immunology
Interferon
Interferon Type I - metabolism
Intestine
Intracellular
Mammals - metabolism
Metabolism
Nematoda
Pathogens
Pest resistance
Review
REVIEW ESSAY
Similarity
Transcription factors
Vertebrates
Viruses
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Summary:Although the type-I interferon (IFN-I) response is considered vertebrate-specific, recent findings about the Intracellular Pathogen Response (IPR) in nematode Caenorhabditis elegans indicate that there are similarities between these two transcriptional immunological programs. The IPR is induced during infection with natural intracellular fungal and viral pathogens of the intestine and promotes resistance against these pathogens. Similarly, the IFN-I response is induced by viruses and other intracellular pathogens and promotes resistance against infection. Whether the IPR and the IFN-I response evolved in a divergent or convergent manner is an unanswered and exciting question, which could be addressed by further studies of immunity against intracellular pathogens in C. elegans and other simple host organisms. Here we highlight similar roles played by RIG-I-like receptors, purine metabolism enzymes, proteotoxic stressors, and transcription factors to induce the IPR and IFN-I response, as well as the similar consequences of these defense programs on organismal development.
ISSN:0265-9247
1521-1878
DOI:10.1002/bies.202300097