Protective Effect of Ticagrelor Against Infective Endocarditis Induced by Virulent Staphylococcus aureus in Mice

In addition to its potent antiplatelet activity, ticagrelor possesses antibacterial properties against gram-positive bacteria. We wondered whether the typical clinical dosage of ticagrelor could prevent the development of infective endocarditis caused by highly virulent . Ticagrelor prevented vegeta...

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Published in:JACC. Basic to translational science 2023-11, Vol.8 (11), p.1439-1453
Main Authors: Oury, Cécile, Meyers, Severien, Jacques, Nicolas, Leeten, Kirsten, Jiang, Zheshen, Musumeci, Lucia, Lox, Marleen, Debuisson, Margaux, Goffin, Eric, Pirotte, Bernard, Delvenne, Philippe, Nchimi, Alain, Hubert, Cédric, Heptia, Mélanie, Hubert, Philippe, Kuijpers, Marijke J E, Vanassche, Thomas, Martinod, Kimberly, Verhamme, Peter, Lancellotti, Patrizio
Format: Article
Language:English
Subjects:
Cardiology and Cardiovascular Medicine
Life sciences
Microbiologie
Microbiology
Original Research - Preclinical
Sciences du vivant
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Summary:In addition to its potent antiplatelet activity, ticagrelor possesses antibacterial properties against gram-positive bacteria. We wondered whether the typical clinical dosage of ticagrelor could prevent the development of infective endocarditis caused by highly virulent . Ticagrelor prevented vegetation formation in a mouse model of inflammation-induced endocarditis. The dosage achieved in patients under ticagrelor therapy altered bacterial toxin production and adherence on activated endothelial cells, thereby mitigating bacterial virulence. Besides the previously described bactericidal activity at high doses, ticagrelor at typical clinical doses possesses antivirulence activity against . Ticagrelor antiplatelet activity further interferes with the interplay between platelets and bacteria.
ISSN:2452-302X
2452-302X
DOI:10.1016/j.jacbts.2023.02.003