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Protective Effect of Ticagrelor Against Infective Endocarditis Induced by Virulent Staphylococcus aureus in Mice
In addition to its potent antiplatelet activity, ticagrelor possesses antibacterial properties against gram-positive bacteria. We wondered whether the typical clinical dosage of ticagrelor could prevent the development of infective endocarditis caused by highly virulent . Ticagrelor prevented vegeta...
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| Published in: | JACC. Basic to translational science 2023-11, Vol.8 (11), p.1439-1453 |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c453t-8c87148fd11db006e9facb847389adf431d906503488ad5cda2c60b579ffd9e73 |
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| cites | cdi_FETCH-LOGICAL-c453t-8c87148fd11db006e9facb847389adf431d906503488ad5cda2c60b579ffd9e73 |
| container_end_page | 1453 |
| container_issue | 11 |
| container_start_page | 1439 |
| container_title | JACC. Basic to translational science |
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| creator | Oury, Cécile Meyers, Severien Jacques, Nicolas Leeten, Kirsten Jiang, Zheshen Musumeci, Lucia Lox, Marleen Debuisson, Margaux Goffin, Eric Pirotte, Bernard Delvenne, Philippe Nchimi, Alain Hubert, Cédric Heptia, Mélanie Hubert, Philippe Kuijpers, Marijke J E Vanassche, Thomas Martinod, Kimberly Verhamme, Peter Lancellotti, Patrizio |
| description | In addition to its potent antiplatelet activity, ticagrelor possesses antibacterial properties against gram-positive bacteria. We wondered whether the typical clinical dosage of ticagrelor could prevent the development of infective endocarditis caused by highly virulent
. Ticagrelor prevented vegetation formation in a mouse model of inflammation-induced endocarditis. The dosage achieved in patients under ticagrelor therapy altered bacterial toxin production and adherence on activated endothelial cells, thereby mitigating bacterial virulence. Besides the previously described bactericidal activity at high doses, ticagrelor at typical clinical doses possesses antivirulence activity against
. Ticagrelor antiplatelet activity further interferes with the interplay between platelets and bacteria. |
| doi_str_mv | 10.1016/j.jacbts.2023.02.003 |
| format | article |
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. Ticagrelor prevented vegetation formation in a mouse model of inflammation-induced endocarditis. The dosage achieved in patients under ticagrelor therapy altered bacterial toxin production and adherence on activated endothelial cells, thereby mitigating bacterial virulence. Besides the previously described bactericidal activity at high doses, ticagrelor at typical clinical doses possesses antivirulence activity against
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. Ticagrelor prevented vegetation formation in a mouse model of inflammation-induced endocarditis. The dosage achieved in patients under ticagrelor therapy altered bacterial toxin production and adherence on activated endothelial cells, thereby mitigating bacterial virulence. Besides the previously described bactericidal activity at high doses, ticagrelor at typical clinical doses possesses antivirulence activity against
. Ticagrelor antiplatelet activity further interferes with the interplay between platelets and bacteria.</description><subject>Cardiology and Cardiovascular Medicine</subject><subject>Life sciences</subject><subject>Microbiologie</subject><subject>Microbiology</subject><subject>Original Research - Preclinical</subject><subject>Sciences du vivant</subject><issn>2452-302X</issn><issn>2452-302X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpVUU1v1DAQjRCIVqX_ACEfuWwYfyRxTqiqWqhUBBIFcRs5_ki9ysaL7ay0_x5vt63KaZ5m5r15o1dV7ynUFGj7aV2vlR5yqhkwXgOrAfir6pSJhq04sD-vX-CT6jylNUDh8U7K5m11wiX0vBP8tNr-iCFbnf3OkivnCiLBkTuv1RjtFCK5GJWfUyY3s3tam03QKhqffSpts2hryLAnv31cJjtn8jOr7f1-CjpovSSilmhL8TP55rV9V71xakr2_LGeVb-ur-4uv65uv3-5uby4XWnR8LySWnZUSGcoNQNAa3tXHpai47JXxglOTQ9tA1xIqUyjjWK6haHpeudMbzt-Vn0-6m6XYWONLsaimnAb_UbFPQbl8f_J7O9xDDukUA5TSYsCPypM3o4WQxw87tgD8wEv04hK42CRsVYiB96KtrA-Pt6N4e9iU8aNT9pOk5ptWBKyHljPmwYOFsVxVceQUrTu2R0FPMSMazzGjIeYERiWmAvtw8vPnklPofJ_xYaoAQ</recordid><startdate>20231101</startdate><enddate>20231101</enddate><creator>Oury, Cécile</creator><creator>Meyers, Severien</creator><creator>Jacques, Nicolas</creator><creator>Leeten, Kirsten</creator><creator>Jiang, Zheshen</creator><creator>Musumeci, Lucia</creator><creator>Lox, Marleen</creator><creator>Debuisson, Margaux</creator><creator>Goffin, Eric</creator><creator>Pirotte, Bernard</creator><creator>Delvenne, Philippe</creator><creator>Nchimi, Alain</creator><creator>Hubert, Cédric</creator><creator>Heptia, Mélanie</creator><creator>Hubert, Philippe</creator><creator>Kuijpers, Marijke J E</creator><creator>Vanassche, Thomas</creator><creator>Martinod, Kimberly</creator><creator>Verhamme, Peter</creator><creator>Lancellotti, Patrizio</creator><general>Elsevier BV</general><general>Elsevier</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>Q33</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7561-0132</orcidid><orcidid>https://orcid.org/0000-0002-1026-6107</orcidid></search><sort><creationdate>20231101</creationdate><title>Protective Effect of Ticagrelor Against Infective Endocarditis Induced by Virulent Staphylococcus aureus in Mice</title><author>Oury, Cécile ; Meyers, Severien ; Jacques, Nicolas ; Leeten, Kirsten ; Jiang, Zheshen ; Musumeci, Lucia ; Lox, Marleen ; Debuisson, Margaux ; Goffin, Eric ; Pirotte, Bernard ; Delvenne, Philippe ; Nchimi, Alain ; Hubert, Cédric ; Heptia, Mélanie ; Hubert, Philippe ; Kuijpers, Marijke J E ; Vanassche, Thomas ; Martinod, Kimberly ; Verhamme, Peter ; Lancellotti, Patrizio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-8c87148fd11db006e9facb847389adf431d906503488ad5cda2c60b579ffd9e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Cardiology and Cardiovascular Medicine</topic><topic>Life sciences</topic><topic>Microbiologie</topic><topic>Microbiology</topic><topic>Original Research - Preclinical</topic><topic>Sciences du vivant</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oury, Cécile</creatorcontrib><creatorcontrib>Meyers, Severien</creatorcontrib><creatorcontrib>Jacques, Nicolas</creatorcontrib><creatorcontrib>Leeten, Kirsten</creatorcontrib><creatorcontrib>Jiang, Zheshen</creatorcontrib><creatorcontrib>Musumeci, Lucia</creatorcontrib><creatorcontrib>Lox, Marleen</creatorcontrib><creatorcontrib>Debuisson, Margaux</creatorcontrib><creatorcontrib>Goffin, Eric</creatorcontrib><creatorcontrib>Pirotte, Bernard</creatorcontrib><creatorcontrib>Delvenne, Philippe</creatorcontrib><creatorcontrib>Nchimi, Alain</creatorcontrib><creatorcontrib>Hubert, Cédric</creatorcontrib><creatorcontrib>Heptia, Mélanie</creatorcontrib><creatorcontrib>Hubert, Philippe</creatorcontrib><creatorcontrib>Kuijpers, Marijke J E</creatorcontrib><creatorcontrib>Vanassche, Thomas</creatorcontrib><creatorcontrib>Martinod, Kimberly</creatorcontrib><creatorcontrib>Verhamme, Peter</creatorcontrib><creatorcontrib>Lancellotti, Patrizio</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Université de Liège - Open Repository and Bibliography (ORBI)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>JACC. 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| identifier | ISSN: 2452-302X |
| ispartof | JACC. Basic to translational science, 2023-11, Vol.8 (11), p.1439-1453 |
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| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10714181 |
| source | ScienceDirect Journals; PubMed Central |
| subjects | Cardiology and Cardiovascular Medicine Life sciences Microbiologie Microbiology Original Research - Preclinical Sciences du vivant |
| title | Protective Effect of Ticagrelor Against Infective Endocarditis Induced by Virulent Staphylococcus aureus in Mice |
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