Expression of HIF-1α in pediatric asthmatic patients

Several studies have suggested that HIF-1α regulates eosinophil activity and induces epithelial inflammation NF-κB activation in the pathophysiology of asthma. The purpose of this study was to examine the expression of the transcription factors HIF-1α and nuclear HIF in mononuclear cells obtained fr...

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Published in:Multidisciplinary respiratory medicine 2023-11, Vol.18 (1), p.927-927
Main Authors: Gonzalez-Uribe, Víctor, Martinez-Tenopala, Ricardo, Osorio-Martínez, Alejandra, Prieto-Gomez, Jimena, Kirsch, Agustin Lammoglia, Alcocer-Arreguin, Christian R, Mojica-Gonzalez, Zaira Selene
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Language:English
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Summary:Several studies have suggested that HIF-1α regulates eosinophil activity and induces epithelial inflammation NF-κB activation in the pathophysiology of asthma. The purpose of this study was to examine the expression of the transcription factors HIF-1α and nuclear HIF in mononuclear cells obtained from peripheral blood samples of healthy pediatric patients, asthmatic patients, and asthmatic exacerbations, regardless of disease severity. HIF-1 levels were measured using immunocytochemistry in 133 patients aged 6 to 17 years in this crosssectional and comparative study. A microscope was used to examine glass slides, and positive cells were counted in four fields per slide using an image analyzer. HIF-1α and nuclear HIF levels were significantly higher in asthma patients and even higher in patients experiencing asthma attacks (p
ISSN:1828-695X
2049-6958
DOI:10.4081/mrm.2023.927