Transmural cellular heterogeneity in myocardial electromechanics

Myocardial heterogeneity is an attribute of the normal heart. We have developed integrative models of cardiomyocytes from the subendocardial (ENDO) and subepicardial (EPI) ventricular regions that take into account experimental data on specific regional features of intracellular electromechanical co...

Full description

Saved in:
Bibliographic Details
Published in:The journal of physiological sciences 2018-07, Vol.68 (4), p.387-413
Main Authors: Khokhlova, Anastasia, Balakina-Vikulova, Nathalie, Katsnelson, Leonid, Iribe, Gentaro, Solovyova, Olga
Format: Article
Language:English
Subjects:
Action potential
Action Potentials - physiology
Analysis
Animal models
Animals
Biomechanical Phenomena - physiology
Calcium
Calcium - metabolism
Cardiology
Cardiomyocytes
Contraction
Electric properties
Electrical properties
Guinea Pigs
Heart
Mechanical properties
Models, Cardiovascular
Myocardial Contraction - physiology
Myocardium - metabolism
Myocytes, Cardiac - physiology
Original Paper
Ventricle
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Myocardial heterogeneity is an attribute of the normal heart. We have developed integrative models of cardiomyocytes from the subendocardial (ENDO) and subepicardial (EPI) ventricular regions that take into account experimental data on specific regional features of intracellular electromechanical coupling in the guinea pig heart. The models adequately simulate experimental data on the differences in the action potential and contraction between the ENDO and EPI cells. The modeling results predict that heterogeneity in the parameters of calcium handling and myofilament mechanics in isolated ENDO and EPI cardiomyocytes are essential to produce the differences in Ca transients and contraction profiles via cooperative mechanisms of mechano-calcium-electric feedback and may further slightly modulate transmural differences in the electrical properties between the cells. Simulation results predict that ENDO cells have greater sensitivity to changes in the mechanical load than EPI cells. These data are important for understanding the behavior of cardiomyocytes in the intact heart.
ISSN:1880-6546
1880-6562
DOI:10.1007/s12576-017-0541-0