Regulation of the glucose supply from capillary to tissue examined by developing a capillary model

A new glucose transport model relying upon diffusion and convection across the capillary membrane was developed, and supplemented with tissue space and lymph flow. The rate of glucose utilization (J ) in the tissue space was described as a saturation function of glucose concentration in the intersti...

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Published in:The journal of physiological sciences 2018-07, Vol.68 (4), p.355-367
Main Authors: Maeda, Akitoshi, Himeno, Yukiko, Ikebuchi, Masayuki, Noma, Akinori, Amano, Akira
Format: Article
Language:English
Subjects:
Animals
Biological Transport
Blood flow
Capillaries
Capillaries - metabolism
Capillary Permeability - physiology
Convection
Dextrose
Diffusion
Glucose
Glucose - metabolism
Glucose transport
Models, Theoretical
Original Paper
Scaling
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cited_by cdi_FETCH-LOGICAL-c650t-aaadc65a955a9e33aad704232cce78186999ca5bfd4468a05989f0617a1d052b3
cites cdi_FETCH-LOGICAL-c650t-aaadc65a955a9e33aad704232cce78186999ca5bfd4468a05989f0617a1d052b3
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container_issue 4
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container_title The journal of physiological sciences
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creator Maeda, Akitoshi
Himeno, Yukiko
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Noma, Akinori
Amano, Akira
description A new glucose transport model relying upon diffusion and convection across the capillary membrane was developed, and supplemented with tissue space and lymph flow. The rate of glucose utilization (J ) in the tissue space was described as a saturation function of glucose concentration in the interstitial fluid (C ), and was varied by applying a scaling factor f to J . With f = 0, the glucose diffusion ceased within ~20 min. While, with increasing f, the diffusion was accelerated through a decrease in C , but the convective flux remained close to resting level. When the glucose supplying capacity of the capillary was measured with a criterion of J /J  = 0.5, the capacity increased in proportion to the number of perfused capillaries. A consistent profile of declining C along the capillary axis was observed at the criterion of 0.5 irrespective of the capillary number. Increasing blood flow scarcely improved the supplying capacity.
doi_str_mv 10.1007/s12576-017-0538-8
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subjects Animals
Biological Transport
Blood flow
Capillaries
Capillaries - metabolism
Capillary Permeability - physiology
Convection
Dextrose
Diffusion
Glucose
Glucose - metabolism
Glucose transport
Models, Theoretical
Original Paper
Scaling
title Regulation of the glucose supply from capillary to tissue examined by developing a capillary model
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