Revisiting and refining roles of neural guidance cues in circuit assembly

Neural guidance mechanisms ensure the precise targeting and synaptogenesis events essential for normal circuit function. Neuronal growth cones encounter numerous attractive and repulsive cues as they navigate toward their intermediate and final targets; temporal and spatial regulation of these respo...

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Bibliographic Details
Published in:Current opinion in neurobiology 2021-02, Vol.66, p.10-21
Main Authors: Dorskind, Joelle M, Kolodkin, Alex L
Format: Article
Language:English
Subjects:
Axon Guidance
Axons
Cues
Growth Cones
Neurons
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Summary:Neural guidance mechanisms ensure the precise targeting and synaptogenesis events essential for normal circuit function. Neuronal growth cones encounter numerous attractive and repulsive cues as they navigate toward their intermediate and final targets; temporal and spatial regulation of these responses are critical for circuit assembly. Recent work highlights the complexity of these events throughout neural development and the multifaceted functions of a wide range of guidance cues. Here, we discuss recent studies that leverage advances in genetics, single cell tracing, transcriptomics and proteomics to further our understanding of the molecular mechanisms underlying neural guidance and overall circuit organization.
ISSN:0959-4388
1873-6882
DOI:10.1016/j.conb.2020.07.005