Towards Cell and Subtype Resolved Functional Organization: Mouse as a Model for the Cortical Control of Movement

•In this review, we consider the mouse as a model for studying the functional organization of motor cortex.•Technical limits have historically precluded resolution of basic functional elements for describing motor circuit mechanisms.•New methods for probing neural function in relation to cell identi...

Full description

Saved in:
Bibliographic Details
Published in:Neuroscience 2020-12, Vol.450, p.151-160
Main Authors: Warriner, Claire L., Fageiry, Samaher K., Carmona, Lina M., Miri, Andrew
Format: Article
Language:English
Subjects:
Animals
behavioral paradigm
cell types
corticospinal
Mice
motor control
Motor Cortex
motor learning
Movement
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•In this review, we consider the mouse as a model for studying the functional organization of motor cortex.•Technical limits have historically precluded resolution of basic functional elements for describing motor circuit mechanisms.•New methods for probing neural function in relation to cell identity features in mice create opportunities for progress. Despite a long history of interrogation, the functional organization of motor cortex remains obscure. A major barrier has been the inability to measure and perturb activity with sufficient resolution to reveal clear functional elements within motor cortex and its associated circuits. Increasingly, the mouse has been employed as a model to facilitate application of contemporary approaches with the potential to surmount this barrier. In this brief essay, we consider these approaches and their use in the context of studies aimed at resolving the logic of motor cortical operation.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2020.07.054