Impact of Cytogenetic Abnormalities on the Risk of Disease Progression in Solitary Bone Plasmacytomas

F0B7Patients with SBP who have high-risk cytogenetic abnormalities by FISH in their clonal plasma cells have a short time to progression to MM.F0B7If there are insufficient clonal plasma cells in the bone marrow, FISH assessment can be performed on the diagnostic SBP tissue. Most patients with SBP p...

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Published in:Blood 2023-11, Vol.142 (22), p.1871-1878
Main Authors: Yadav, Udit, Kumar, Shaji K., Baughn, Linda B., Dispenzieri, Angela, Greipp, Patricia, Ketterling, Rhett, Jevremovic, Dragan, Buadi, Francis K., Dingli, David, Lacy, Martha Q., Fonseca, Rafael, Bergsagel, Leif, Ailawadhi, Sikander, Roy, Vivek, Parrondo, Ricardo, Sher, Taimur, Hayman, Suzanne R., Kapoor, Prashant, Leung, Nelson, Cook, Joselle, Binder, Moritz, Muchtar, Eli, Warsame, Rahma, Kourelis, Taxiarchis V., Go, Ronald S., Lin, Yi, Seth, Abhishek, Lester, Scott C., Breen, William G., Kyle, Robert A., Gertz, Morie A., Rajkumar, S. Vincent, Gonsalves, Wilson I.
Format: Article
Language:English
Subjects:
Chromosome Aberrations
Clinical Trials and Observations
Disease Progression
Humans
In Situ Hybridization, Fluorescence
Multiple Myeloma - diagnosis
Multiple Myeloma - genetics
Plasmacytoma - genetics
Prognosis
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Summary:F0B7Patients with SBP who have high-risk cytogenetic abnormalities by FISH in their clonal plasma cells have a short time to progression to MM.F0B7If there are insufficient clonal plasma cells in the bone marrow, FISH assessment can be performed on the diagnostic SBP tissue. Most patients with SBP progress to MM after definitive radiation therapy as their primary treatment. Whether the presence of high-risk (HR) cytogenetic abnormalities by FISH in the clonal plasma cells, obtained either directly from the diagnostic SBP tissue or the corresponding bone marrow examination at the time of diagnosis, is associated with a shorter time to progression (TTP) to MM is unknown. This study evaluated all patients diagnosed with SBP at the Mayo Clinic from January 2012 to July 2022. The presence of del(17p), t(14;16), t(4;14), or +1q (gain or amplification) by FISH in clonal plasma cells was defined as HR. A total of 114 patients were included in this cohort, and baseline FISH was available for 55 patients (48%), of which 22 were classified as HR (40%). The median TTP to MM for patients with SBP and HR FISH was 8 months (95%CI: 6.3-26) compared to 42 months (95%CI: 25-NR) in patients with SBP without HR FISH (p
ISSN:0006-4971
1528-0020
1528-0020
DOI:10.1182/blood.2023021187