Clinical and [18F] dopa PET findings in early Parkinson's disease

Twenty seven patients with recent onset (mean symptom duration 22 (SD 14) months, Hoehn and Yahr score 1.8 (SD 0.7)) Parkinson's disease were studied with [18F]dopa PET. There was a correlation between putamen influx (Ki) and clinical rating, but not symptom duration. In 11 patients with hemi-P...

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Bibliographic Details
Published in:Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 1995-12, Vol.59 (6), p.597-600
Main Authors: Morrish, P K, Sawle, G V, Brooks, D J
Format: Article
Language:English
Subjects:
Antiparkinson Agents - therapeutic use
Biological and medical sciences
Case-Control Studies
Dihydroxyphenylalanine - analogs & derivatives
Discriminant Analysis
Female
Fluorine Radioisotopes
Humans
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Middle Aged
Nervous system
Parkinson Disease - diagnostic imaging
Parkinson Disease - drug therapy
Predictive Value of Tests
Putamen - diagnostic imaging
Radionuclide investigations
Selegiline - therapeutic use
Severity of Illness Index
Time Factors
Tomography, Emission-Computed
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Summary:Twenty seven patients with recent onset (mean symptom duration 22 (SD 14) months, Hoehn and Yahr score 1.8 (SD 0.7)) Parkinson's disease were studied with [18F]dopa PET. There was a correlation between putamen influx (Ki) and clinical rating, but not symptom duration. In 11 patients with hemi-Parkinson's disease of recent onset there were significant differences between normal (mean 0.0123 (SD 0.0023)), asymptomatic (mean 0.0099 (0.0020)) and symptomatic (mean 0.0070 (00.014)) putamen Kis. This suggests that Parkinson's disease has a widely variable rate of progression, and is most compatible with a short preclinical period. Symptom onset was estimated at a putamen Ki of between 57% and 80% of normal. Most ipsilateral putamen Ki values in early asymmetric Parkinson's disease fell within the normal range. The implication is that either the disease is not established in the ipsilateral putamen or that the technique is insufficiently sensitive to detect it. Discriminant analysis completely separated the normal and Parkinson's disease cohorts, but when a discriminant function from a previous study was used predictively four of the 27 patients with Parkinson's disease were incorrectly classified as normal.
ISSN:0022-3050
1468-330X
DOI:10.1136/jnnp.59.6.597