Efficient post-synthesis incorporation and conjugation of reactive ketones in RNA via 2'-acylation

Despite the broad utility of ketones in bioconjugation, few methods exist to introduce them into RNA. Here we develop highly reactive 2'-OH acylating reagents containing strained-ring ketones, and employ them as versatile labeling handles for RNA.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2023-12, Vol.60 (2), p.232-235
Main Authors: Shioi, Ryuta, Xiao, Lu, Fang, Linglan, Kool, Eric T
Format: Article
Language:English
Subjects:
Acylation
Conjugation
Indicators and Reagents
Ketones
Reagents
RNA - genetics
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Description
Summary:Despite the broad utility of ketones in bioconjugation, few methods exist to introduce them into RNA. Here we develop highly reactive 2'-OH acylating reagents containing strained-ring ketones, and employ them as versatile labeling handles for RNA.
ISSN:1359-7345
1364-548X
DOI:10.1039/d3cc05123d