An Autopsy Case of Post-COVID-19 Interstitial Lung Disease with Acute Exacerbation

The prognosis of patients with post-coronavirus disease 2019 (COVID-19) interstitial lung disease remains unclear. We herein report an autopsy case in which serial progression after the onset of post-COVID-19 interstitial lung disease resulted in an acute exacerbation, leading to a fatal outcome. Au...

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Bibliographic Details
Published in:Internal Medicine 2023/12/01, Vol.62(23), pp.3519-3523
Main Authors: Tsuzuku, Akifumi, Asano, Fumihiro, Katayama, Masaki, Mori, Kosuke, Sasaki, Yui, Kuzunishi, Yutaro, Taguchi, Mayuka, Muto, Yuya, Baba, Yasutomo, Tsuchida, Akimasa, Kato, Tomoya, Murakami, Anri, Masuda, Atsunori, Yoshizane, Takashi, Suzuki, Jun
Format: Article
Language:English
Subjects:
Autopsy
autopsy pathology
Case Report
Coronaviruses
COVID-19
COVID-19 - complications
diffuse alveolar damage
Fibrosis
Humans
Inflammation
Internal medicine
interstitial lung disease
Lung diseases
Lung Diseases, Interstitial - complications
Lung Diseases, Interstitial - pathology
post-COVID-19
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Summary:The prognosis of patients with post-coronavirus disease 2019 (COVID-19) interstitial lung disease remains unclear. We herein report an autopsy case in which serial progression after the onset of post-COVID-19 interstitial lung disease resulted in an acute exacerbation, leading to a fatal outcome. Autopsy findings included hyaline membrane formation/interstitial inflammatory cell infiltration, suggestive of acute lesions, and severe regional fibrosis, indicating a preexisting chronic condition. In the present case, we histopathologically confirmed the acute exacerbation of post-COVID-19 interstitial lung disease.
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.2006-23