Nutritional index in relation to prognosis of endometrial cancer

Evaluate the prognostic value of the prognostic nutritional index (PNI) in patients with endometrial cancer (EC). Laboratory and clinicopathological data from 370 patients who were diagnosed with EC between January 2010 and December 2021 were reviewed. The PNI was analyzed for correlations with recu...

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Bibliographic Details
Published in:International journal of medical sciences 2024, Vol.21 (1), p.169-174
Main Authors: Gen, Yuki, Yun, Jisu, Ahn, Jimin, Yoon, Joo Hee, Park, Dong Choon, Kim, Sang Il
Format: Article
Language:English
Subjects:
Body mass index
Cancer therapies
Chemotherapy
Disease
Endometrial cancer
Histology
Laparoscopy
Lymphatic system
Medical prognosis
Metastasis
Nutritional status
Patients
Radiation therapy
Research Paper
Surgery
Uterine cancer
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Summary:Evaluate the prognostic value of the prognostic nutritional index (PNI) in patients with endometrial cancer (EC). Laboratory and clinicopathological data from 370 patients who were diagnosed with EC between January 2010 and December 2021 were reviewed. The PNI was analyzed for correlations with recurrence and survival. The receiver operating characteristic curves were generated for the PNI. Optimal cut-off values were determined as the points at which the Youden index (sensitivity + specificity - 1) was maximal. Based on the results of the ROC curve analysis, the patients were grouped into high and low PNI groups. Differences in the clinicopathological characteristics between patients with high and low PNI were compared between the two groups. The effects of the prognostic factors were analyzed using univariate and multivariate Cox proportional hazards model. The optimal cutoff value of the PNI was 52.74 for DFS (area under the curve: 0.817; 95% CI: 0.738-0.858,
ISSN:1449-1907
1449-1907
DOI:10.7150/ijms.87752