Prevalence of cervical precancers or cancers in women with ASC-H/HSIL cytology according to Aptima HPV (AHPV) assay-detected HPV genotypes and age

: Aimed to potentially risk-stratify patients with different cervical cytology diagnoses, by HPV genotypes and/or age, we have conducted a series of studies to examine the prevalence of cervical precancers and cancers for women with different cytology diagnoses. This paper will be focusing on patien...

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Bibliographic Details
Published in:Journal of Cancer 2024, Vol.15 (1), p.140-148
Main Authors: Liu, Qin, Chen, Liqing, Yu, Minghua, Zhou, Xin, Zhang, Xiaofei, Zheng, Wenxin, Niu, Shuang, Zhou, Feng
Format: Article
Language:English
Subjects:
Age groups
Biopsy
Cellular biology
Cervical cancer
Human papillomavirus
Infections
Medical screening
Pathology
Research Paper
Womens health
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Summary:: Aimed to potentially risk-stratify patients with different cervical cytology diagnoses, by HPV genotypes and/or age, we have conducted a series of studies to examine the prevalence of cervical precancers and cancers for women with different cytology diagnoses. This paper will be focusing on patients with ASC-H/HSIL cytology. : In total, 1183 patients aged 20-78 years with atypical squamous cells, cannot rule out HSIL (ASC-H)/HSIL by cytology underwent AHPV assay and cervical biopsy in a developed region in southern China were included in this study. : Overall, 59.2% women with ASC-H/HSIL cytology had cervical intraepithelial neoplasia (CIN)2/3 lesions while 1.6% had adenocarcinoma (AIS) lesions. Compared to other groups, HPV-16+ group (80.8%) showed a significantly higher prevalence of CIN2/3 than other genotype+ groups (p
ISSN:1837-9664
1837-9664
DOI:10.7150/jca.89715