Kelch-like Protein 11 (KLHL11) Antibodies in Children With Seizures of Undetermined Cause

Kelch-like protein 11 (KLHL11)-antibody may be found in paraneoplastic neurological disorders presenting with epileptic seizures. The aim of this study was to investigate the prevalence and clinical significance of KLHL11-antibody in epilepsy. Sera of 42 pediatric and 59 adult patients with seizures...

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Bibliographic Details
Published in:In vivo (Athens) 2024-01, Vol.38 (1), p.351-357
Main Authors: Tzartos, John, Pechlivanidou, Maria, Bosveli, Despoina, Ninou, Elpinickie, Yuceer, Hande, Yalcin, Beyzanur, Kucukali, Cem Ismail, Tuzun, Erdem, Tzartos, Socrates, Turkdogan, Dilsad
Format: Article
Language:English
Subjects:
Carrier Proteins
Child
Child, Preschool
Disease Progression
Electroencephalography
Epilepsy
Female
Humans
Male
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Summary:Kelch-like protein 11 (KLHL11)-antibody may be found in paraneoplastic neurological disorders presenting with epileptic seizures. The aim of this study was to investigate the prevalence and clinical significance of KLHL11-antibody in epilepsy. Sera of 42 pediatric and 59 adult patients with seizures of undetermined cause were screened using a cell-based assay. KLHL11-antibody was found in three of 168 control patients with paraneoplastic neurological disorders and four pediatric patients (4-8-year-old, 2 boys/2 girls) with seizures of unknown cause presenting with myoclonic-atonic epilepsy, generalized epilepsy or childhood epilepsy with centrotemporal spikes. In these four cases, seizures continued for 2-7 months, responded promptly and favorably to conventional anti-seizure drugs and did not recur in follow-up durations ranging between 2-5 years. Patients had normal brain MRI findings and motor-mental development before and after seizures. KLHL11-antibody was not detected in adult epilepsy patients with undetermined cause, MOG antibody-positive patients and healthy controls. KLHL11-antibody may be detected in pediatric epilepsy patients with a relatively benign disease course.
ISSN:0258-851X
1791-7549
DOI:10.21873/invivo.13445