Changes in Urinary Exosomal Nuclear Matrix Protein-22 in Dogs With Urothelial Carcinoma: A Pilot Study

Nuclear matrix protein-22 (NMP-22) is widely used in human medicine as a prognostic and diagnostic tool for urothelial carcinoma (UC). In addition, the use of urinary exosomes as a liquid biopsy tool is emerging for the diagnosis of certain types of cancer in human medicine. This study aimed to inve...

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Bibliographic Details
Published in:In vivo (Athens) 2024-01, Vol.38 (1), p.190-195
Main Authors: Shin, Jee-Hyo, An, Ju-Hyun, Park, Su-Min, Lim, Ga-Hyun, Seo, Kyoung-Won, Youn, Hwa-Young
Format: Article
Language:English
Subjects:
Animals
Biomarkers, Tumor - urine
Carcinoma, Transitional Cell - diagnosis
Carcinoma, Transitional Cell - pathology
Carcinoma, Transitional Cell - veterinary
Dogs
Humans
Nuclear Matrix-Associated Proteins
Pilot Projects
Urinary Bladder Neoplasms - pathology
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Summary:Nuclear matrix protein-22 (NMP-22) is widely used in human medicine as a prognostic and diagnostic tool for urothelial carcinoma (UC). In addition, the use of urinary exosomes as a liquid biopsy tool is emerging for the diagnosis of certain types of cancer in human medicine. This study aimed to investigate the change in urinary exosomal NMP-22 for the diagnosis of UC in dogs. Among canine patients who visited the veterinary hospital, urine was collected from those whose owners provided consent. A total of 23 dogs (UC group, n=6; control group, n=17) were included in the analysis. After exosomes were isolated from the urine, NMP-22 was measured using enzyme-linked immunosorbent assay. In the UC group, the expression of NMP-22 in urinary exosomes was significantly higher than that in non-UC groups (p
ISSN:0258-851X
1791-7549
DOI:10.21873/invivo.13425