Navigating the Landscape of Hydrocortisone Administration in Septic Shock: Current Concepts and Future Directions

Sepsis remains a formidable challenge in critical care medicine, often culminating in a life-threatening condition known as septic shock. This review article navigates the intricate landscape of hydrocortisone administration in septic shock management, delving into historical perspectives, current e...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2023-12, Vol.15 (12), p.e49870-e49870
Main Authors: Kommareddy, Jr, Anirudh, Vagha, Jayant D, Meshram, Revat J
Format: Article
Language:English
Subjects:
Adrenal glands
Blood pressure
Blood vessels
Clinical trials
Cytokine storm
Glucose
Hemodynamics
Hormones
Hypotension
Immune system
Infections
Inflammation
Medical Education
Medical Simulation
Pathogens
Patients
Permeability
Precision medicine
Sepsis
Steroids
Tumor necrosis factor-TNF
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Summary:Sepsis remains a formidable challenge in critical care medicine, often culminating in a life-threatening condition known as septic shock. This review article navigates the intricate landscape of hydrocortisone administration in septic shock management, delving into historical perspectives, current evidence, controversies, mechanisms of action, practical considerations, and the importance of precision medicine. Hydrocortisone's role as an adjunctive therapy is explored, highlighting its potential to stabilize hemodynamics, mitigate the inflammatory response, and improve patient outcomes. However, debates persist regarding patient selection, dosing regimens, safety profiles, and long-term consequences. The future of septic shock management lies in emerging therapies, precision medicine approaches, biomarker discovery, and targeted interventions. Moving forward, exploring novel therapeutic avenues, understanding patient-specific responses, and uncovering potential biomarkers will be crucial in advancing septic shock treatment strategies. Clinical guidelines provide a foundation, but individualized patient care, interdisciplinary collaboration, and ongoing research are essential to optimize treatment strategies. This article underscores the call for continued research and evidence-based practice as we strive to enhance the care of septic shock patients and pursue improved outcomes in this critical condition. Embracing future developments in the field will enable us to adapt and refine our approach, ultimately contributing to the advancement of septic shock management.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.49870