Investigation of the in vitro biological activities of polyethylene glycol-based thermally stable polyurethane elastomers

• Published in: RSC advances 2024-01, Vol.14 (2), p.779-793
• Main Authors: Akram, Nadia, Shahbaz, Muhammad, Zia, Khalid Mahmood, Usman, Muhammad, Ali, Akbar, Al-Salahi, Rashad, Abuelizz, Hatem A, Delattre, Cédric
• Format: Article
• Language: English
• Subjects: Chemistry; Diisocyanates; Dynamic mechanical analysis; Dynamic stability; E coli; Elastomers; Fourier transforms; Infrared analysis; Monomers; Phase contrast; Polyethylene glycol; Polyurethane resins; Prepolymers; Stability analysis; Storage modulus; Thermal analysis; Thermal stability; Thermogravimetric analysis
• ISSN: 2046-2069; 2046-2069
• DOI: 10.1039/d3ra06997d

The intense urge to replace conventional polymers with ecofriendly monomers is a step towards green products. The novelty of this study is the extraction of starch from the biowaste of wheat bran (WB) and banana peel (BP) for use as a monomer in the form of chain extenders. For the synthesis of polyurethane (PU) elastomers, polyethylene glycol (PEG) bearing an average molecular weight = 1000 g mol was used as a macrodiol, which was reacted with isophorone diisocyanate (IPDI) to develop NCO-terminated prepolymer chains. These prepolymer chains were terminated with chain extenders. Two series of linear PU elastomers were prepared by varying the concentration of chain extenders (0.5-2.5 mol%), inducing a variation of 40 to 70 wt% in the hard segment (HS). Fourier-transform infrared (FTIR) spectroscopy confirmed the formation of urethane linkages. Thermal gravimetric analysis (TGA) showed a thermal stability of up to 250 °C. Dynamic mechanical analysis (DMA) revealed a storage modulus ( ') of up to 140 MPa. Furthermore, the hemolytic activities of up to 8.97 ± 0.1% were recorded. The inhibition of biofilm formation was investigated against and (%), which was supported by phase contrast microscopy.