Use of Proton Pump Inhibitors and Risk of Fracture in Adults: A Review of Literature

Proton pump inhibitors (PPIs) are commonly used medications for various gastrointestinal disorders and are reported to be associated with bone fractures. A literature review was performed, which showed PPI to be associated with a shorter time to first fracture in adults aged 25 or older. There was a...

Full description

Saved in:
Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2023-12, Vol.15 (12), p.e49872-e49872
Main Authors: Paudel, Yubraj, Najam, Beenish, Desai, Heet N, Illango, Janan, Seffah, Kofi D, Kumar, Mahendar, Naveen, Namballa, Pachchipulusu, Vamsi Krishna, Penumetcha, Sai Sri
Format: Article
Language:English
Subjects:
Acids
Adenosine triphosphate
Adults
Bisphosphonates
Bone density
Clinical trials
Cohort analysis
Disease
Double-blind studies
Fractures
Gastroenterology
Histamine
Kidney transplants
Literature reviews
Meta-analysis
Observational studies
Orthopedics
Protons
Risk factors
Systematic review
Therapeutics
Vitamin D
Womens health
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Proton pump inhibitors (PPIs) are commonly used medications for various gastrointestinal disorders and are reported to be associated with bone fractures. A literature review was performed, which showed PPI to be associated with a shorter time to first fracture in adults aged 25 or older. There was an overall increased risk of fractures with PPI use in adults; however, such risk was not significantly higher in women over 80 years of age and adult patients with rheumatoid arthritis. In healthy adult males aged 18-50 years, PPI use was not associated with significant changes in calcium and bone metabolism with PPI use. The lack of increased risk among elderly women aged more than 80 and rheumatoid arthritis patients raises the possible confounding or effect modification by factors that affect the fracture risk with PPI use. We concluded that although observational studies show an increased risk of fractures with PPI use, warranting their use with caution in some patients, experimental evidence explaining the risk is still lacking.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.49872