Transvaginal approach combined intracavitary and interstitial brachytherapy assisted by transrectal ultrasound: results from 30 patients with locally advanced cervical cancer

Purpose This study evaluated the efficacy and safety of transvaginal approach combined intracavitary and interstitial brachytherapy (IC/IS BT) assisted by transrectal ultrasound (TRUS) for treatment of locally advanced cervical cancer (LACC). Materials and Methods A total of 30 patients of LACC trea...

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Bibliographic Details
Published in:Japanese journal of radiology 2024-01, Vol.42 (1), p.96-101
Main Authors: Nakashima, Takaaki, Matsumoto, Keiji, Yoshitake, Tadamasa, Wakiyama, Hiroaki, Hisano, Osamu, Uehara, Ryuji, Takaki, Masanori, Oshima, Takeshi, Yahata, Hideaki, Ishigami, Kousei
Format: Article
Language:English
Subjects:
Adverse events
Brachytherapy
Brachytherapy - methods
Cancer
Cervical cancer
Complications
Female
Humans
Imaging
Medicine
Medicine & Public Health
Nuclear Medicine
Original
Original Article
Radiation therapy
Radiology
Radiotherapy
Radiotherapy Dosage
Radiotherapy Planning, Computer-Assisted - methods
Retrospective Studies
Safety
Survival
Ultrasonic imaging
Ultrasound
Uterine Cervical Neoplasms - diagnostic imaging
Uterine Cervical Neoplasms - radiotherapy
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Summary:Purpose This study evaluated the efficacy and safety of transvaginal approach combined intracavitary and interstitial brachytherapy (IC/IS BT) assisted by transrectal ultrasound (TRUS) for treatment of locally advanced cervical cancer (LACC). Materials and Methods A total of 30 patients of LACC treated with external beam radiotherapy and IC/IS BT via transvaginal approach assisted by transrectal ultrasound were observed retrospectively. The 2-year local control (LC), progression-free survival (PFS), and overall survival (OS) were analyzed using the Kaplan–Meier method. Late adverse events were also evaluated to assess the safety of IC/IS BT. Results The median follow-up period was 22 months. The 2-year LC, PFS, and OS were 90%, 61%, and 82%, respectively. We observed no critical complications related to the IC/IS BT technique. Late adverse events of grade 3 or more included one case of grade 4 colon perforation. Conclusion Our patient series demonstrated that radiotherapy combined with transvaginal approach, TRUS-assisted IC/IS BT achieves favorable local control and safety for LACC.
ISSN:1867-1071
1867-108X
DOI:10.1007/s11604-023-01481-4