Allicin and Omega-3 fatty acids attenuates acetaminophen mediated renal toxicity and modulates oxidative stress, and cell apoptosis in rats

Acetaminophen (APAP), a widely used medication known for its pain-relieving and fever-reducing effects, can cause kidney failure if taken in excess. To investigate the potential protective effects of allicin (ALC) and/or omega-3 fatty acids (O3FA) against acetaminophen-induced kidney damage, a study...

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Bibliographic Details
Published in:Naunyn-Schmiedeberg's archives of pharmacology 2024-01, Vol.397 (1), p.317-328
Main Authors: Elsafty, Moamen, Abdeen, Ahmed, Aboubakr, Mohamed
Format: Article
Language:English
Subjects:
Acetaminophen
Analgesics
Apoptosis
Biomedical and Life Sciences
Biomedicine
Caspase-3
Creatinine
Fatty acids
Glutathione
Hsp70 protein
Inflammation
Kidneys
Neurosciences
Omega-3 fatty acids
Oxidative stress
Pharmacology/Toxicology
Renal failure
Toxicity
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Summary:Acetaminophen (APAP), a widely used medication known for its pain-relieving and fever-reducing effects, can cause kidney failure if taken in excess. To investigate the potential protective effects of allicin (ALC) and/or omega-3 fatty acids (O3FA) against acetaminophen-induced kidney damage, a study was conducted using 49 rats divided into seven groups. The control group was given saline, while the other groups received ALC, O3FA, APAP, ALC + APAP, O3FA + APAP, or ALC + O3FA + APAP. After administering APAP, the rats showed decreased levels of total protein and albumin in their blood, along with increased levels of creatinine and urea. The concentration of reduced glutathione (GSH), as well as the activity of superoxide dismutase (SOD) and catalase (CAT), decreased, while the level of malondialdehyde (MDA) in the renal tissues increased. The activation of caspase-3 and HSP70 also suggested an impact on kidney histopathology. Overall, the study found that ALC and/or O3FA may have a protective impact against acetaminophen-induced kidney damage through their anti-inflammatory, anti-apoptotic, and antioxidant defense systems.
ISSN:0028-1298
1432-1912
DOI:10.1007/s00210-023-02609-z