Does vitamin D protect or treat Parkinson’s disease? A narrative review

Parkinson’s disease (PD) is a neurodegenerative brain disease (NBD) developed due to dopaminergic neuron loss in the substantia nigra (SN). Vitamin D (VD), VD receptor (VDR), and VD metabolites are highly expressed in the human brain and play a critical role in maintaining different brain functions....

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Bibliographic Details
Published in:Naunyn-Schmiedeberg's archives of pharmacology 2024-01, Vol.397 (1), p.33-40
Main Authors: Al-kuraishy, Hayder M., Al-Gareeb, Ali I., Selim, Hend Mostafa, Alexiou, Athanasios, Papadakis, Marios, Negm, Walaa A., Batiha, Gaber El-Saber
Format: Article
Language:English
Subjects:
Archives & records
Biomedical and Life Sciences
Biomedicine
Brain
Disease
Dopamine receptors
Endoplasmic reticulum
Genes
Homeostasis
Inflammation
Metabolites
Movement disorders
Neurodegenerative diseases
Neurons
Neurosciences
Oxidative stress
Parkinson's disease
Pharmacology
Pharmacology/Toxicology
Pharmacy
Proteins
Review
Sexually transmitted diseases
STD
Steroids
Substantia nigra
Synaptic plasticity
Vitamin D
Vitamin D receptors
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Summary:Parkinson’s disease (PD) is a neurodegenerative brain disease (NBD) developed due to dopaminergic neuron loss in the substantia nigra (SN). Vitamin D (VD), VD receptor (VDR), and VD metabolites are highly expressed in the human brain and play a critical role in maintaining different brain functions. VDRs are highly expressed in the SN that regulates the activity of dopaminergic neurons and synaptic plasticity. VD exerts protective and therapeutic effects against the development of PD by modulating dopaminergic neurons of SN. VD reduces oxidative stress and neuroinflammation in PD because of its anti-inflammatory and antioxidant activities. Different studies revealed the protective effect of VD in the management of PD. However, the potential therapeutic effect of VD in well-established PD remains controversial. Therefore, this review aims to elucidate VD’s preventive and therapeutic roles in PD. In conclusion, VD deficiency is associated with increased PD risk, but VD supplementation in well-established PD plays little role.
ISSN:0028-1298
1432-1912
DOI:10.1007/s00210-023-02656-6