Autoimmune Thyroid Disease in Psoriasis Patients: A Case-Control Study

Psoriasis is a common immunologically mediated inflammatory disease characterized by skin inflammation, epidermal hyperplasia, an increased risk of painful and destructive arthritis, cardiovascular morbidity, and psychosocial challenges. Some autoimmune diseases are mediated by stimulating or blocki...

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Published in:Curēus (Palo Alto, CA) CA), 2023-12, Vol.15 (12), p.e50197-e50197
Main Authors: Prashant, Praveen, Garg, Renu, Kataria, Usha, Vashist, Sonia, Bansal, Piyush, Prakash, Gulshan, Dokwal, Sumit, Bansal, Abhishek
Format: Article
Language:English
Subjects:
Age
Allergy/Immunology
Antibodies
Autoimmune diseases
Chi-square test
Dermatology
Females
Hyperthyroidism
Males
Mann-Whitney U test
Medical prognosis
Pathology
Psoriasis
Quality control
Skin
Statistical analysis
Thyroid diseases
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Summary:Psoriasis is a common immunologically mediated inflammatory disease characterized by skin inflammation, epidermal hyperplasia, an increased risk of painful and destructive arthritis, cardiovascular morbidity, and psychosocial challenges. Some autoimmune diseases are mediated by stimulating or blocking auto-antibodies. Auto-antibodies may act as antagonists and bind to hormone receptors, blocking receptor function. It may result in impaired secretion of mediators and gradual dysfunction of the affected organ, e.g., Graves disease and myasthenia gravis. This study was planned to evaluate the association between anti-thyroid peroxidase antibody (anti-TPO Ab) and anti-thyroglobulin antibody (anti-TG Ab) as biochemical markers in 30 clinically diagnosed psoriasis patients. This hospital-based, epidemiological case-control study was conducted in the Department of Biochemistry in collaboration with the Department of Dermatology, Venereology, and Leprology at Bhagat Phool Singh Government Medical College for Women, Khanpur Kalan, Sonepat, Haryana, India. Thirty subjects diagnosed clinically with psoriasis and an equal number of age-matched controls with no known autoimmune disease from the outpatient department were also enrolled. The following hormonal tests, i.e., thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), and antibodies, anti-TPO Ab and anti-TG Ab, were performed. The study period was one year. The data thus obtained was analyzed using SPSS Statistics version 26.0 (IBM Corp. Released 2019. IBM SPSS Statistics for Windows, Version 26.0. Armonk, NY: IBM Corp). The significance level (p-value) was taken as
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.50197