Thyroid status in pregnancy: Comparison of thyroid function abnormalities in women with and without a history of miscarriage or stillbirth

To evaluate thyroid function tests (TFTs) during pregnancy in women with previous history of miscarriage or stillbirth. A cross-sectional study was carried out at the department of Obstetrics & Gynaecology and Endocrinology, Lady Reading Hospital, Peshawar from February 2021 to March 2022. All m...

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Bibliographic Details
Published in:Pakistan journal of medical sciences 2024-01, Vol.40 (1Part-I), p.179-184
Main Authors: Abbas, Ghulam, Sabir, Samina Aliya, Rehman, Siddiq Ur, Gohar, Beenish
Format: Article
Language:English
Subjects:
Age
Analysis
Antibodies
Ethics
Hyperthyroidism
Hypothyroidism
Miscarriage
Mortality
Original
Preeclampsia
Pregnancy
Pregnant women
Still-birth
Stillbirth
Thyroid gland
Thyroid hormones
Womens health
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Summary:To evaluate thyroid function tests (TFTs) during pregnancy in women with previous history of miscarriage or stillbirth. A cross-sectional study was carried out at the department of Obstetrics & Gynaecology and Endocrinology, Lady Reading Hospital, Peshawar from February 2021 to March 2022. All multigravida women attending the antenatal clinics were included using consecutive sampling. These women were placed into two groups, Group-A comprised of women with no prior history of miscarriages or stillbirths, and those with a history of foetal death during previous pregnancies were assigned Group-B. Free T4, thyroid stimulating hormone (TSH) and anti-thyroid peroxidase (TPO) antibodies were measured and the former two were used to label patients with thyroid dysfunction. A total of 139 multigravida women were included in the study. About 43% of the women had a history of miscarriages or stillbirths. Thyroid dysfunction was observed overall in 36.69 % women, of whom 25.18% had sub-clinical hypothyroidism, 6.47% had hypothyroidism and 5.04 % were sub-clinical hyperthyroid. Women in Group-B had more thyroid functions abnormalities compared to Group-A (p
ISSN:1682-024X
1681-715X
DOI:10.12669/pjms.40.1.7282