Comparison of risk factors for Methicillin Resistant Staphylococcus aureus (MRSA) colonization in healthy newborns, born to mothers with and without MRSA colonization

• Published in: Pakistan journal of medical sciences 2024-01, Vol.40 (1Part-I), p.84-88
• Main Authors: Malik, Sara, Afzal, Muhammad Faheem, Hamid, Muhammad Haroon
• Format: Article
• Language: English
• Subjects: Antibiotics; Babies; Birth weight; Comparative analysis; Diseases; Drug resistance in microorganisms; Feces; Gender; Infants (Newborn); Infants (Premature); Infection; Intensive care; Membranes; Methicillin; Mothers; Mupirocin; Neonatal intensive care; Neonatology; Original; Pregnancy; Regression analysis; Risk factors; Staphylococcus aureus; Staphylococcus aureus infections; Staphylococcus infections; Vagina
• ISSN: 1682-024X; 1681-715X
• DOI: 10.12669/pjms.40.1.7703

To compare the risk factors for MRSA colonization in healthy newborns, born of mothers with and without MRSA colonization. This case control study was conducted in post-natal unit of Lady Willingdon Hospital, affiliated with King Edward Medical University/Mayo Hospital, Lahore from January to June 2017. The vaginal and anterior nares swabs for MRSA culture were collected from mothers within six hours before planned delivery and the neonatal anterior nares swabs for MRSA culture were taken within one hour of birth. All the samples were cultured in Paediatric Microbiology laboratory in Mayo Hospital. Data were analyzed through SPSS 20.0 and logistic regression was applied for risk factors analysis. Out of total 80 mothers and their newborns, 15 (18.75%) mothers and 16 neonates (20%) were MRSA colonized. The frequency of MRSA colonization in mothers' anterior nares and vaginal swab was 17.5% and 1.25% respectively. The significant risk factors were prolonged rupture of membranes for >18 hours (p-value 0.02, odds ratio 11.85, 95% CI 1.41-99.3), birth weight