TGF-β signaling in health and disease

The TGF-β regulatory system plays crucial roles in the preservation of organismal integrity. TGF-β signaling controls metazoan embryo development, tissue homeostasis, and injury repair through coordinated effects on cell proliferation, phenotypic plasticity, migration, metabolic adaptation, and immu...

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Bibliographic Details
Published in:Cell 2023-09, Vol.186 (19), p.4007-4037
Main Authors: Massagué, Joan, Sheppard, Dean
Format: Article
Language:English
Subjects:
Adaptation, Physiological
Animals
Cell Proliferation
Embryonic Development
Signal Transduction
Transforming Growth Factor beta
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Summary:The TGF-β regulatory system plays crucial roles in the preservation of organismal integrity. TGF-β signaling controls metazoan embryo development, tissue homeostasis, and injury repair through coordinated effects on cell proliferation, phenotypic plasticity, migration, metabolic adaptation, and immune surveillance of multiple cell types in shared ecosystems. Defects of TGF-β signaling, particularly in epithelial cells, tissue fibroblasts, and immune cells, disrupt immune tolerance, promote inflammation, underlie the pathogenesis of fibrosis and cancer, and contribute to the resistance of these diseases to treatment. Here, we review how TGF-β coordinates multicellular response programs in health and disease and how this knowledge can be leveraged to develop treatments for diseases of the TGF-β system. Defects of TGF-β signaling can give rise to multiple diseases, including chronic inflammation, fibrosis, and cancer. This comprehensive review covers how TGF-β coordinates multicellular response programs in health and disease and how this knowledge can be leveraged to develop treatments for diseases of the TGF-β system.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2023.07.036