Optically Guided High-Frequency Ultrasound Shows Superior Efficacy for Preoperative Estimation of Breslow Thickness in Comparison with Multispectral Imaging: A Single-Center Prospective Validation Study

Melanoma is the most aggressive form of skin cancer that is known for its metastatic potential and has an increasing incidence worldwide. Breslow thickness, which determines the staging and surgical margin of the tumor, is unavailable at initial diagnosis. Novel imaging techniques for assessing Bres...

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Bibliographic Details
Published in:Cancers 2023-12, Vol.16 (1), p.157
Main Authors: Varga, Noémi Nóra, Boostani, Mehdi, Farkas, Klára, Bánvölgyi, András, Lőrincz, Kende, Posta, Máté, Lihacova, Ilze, Lihachev, Alexey, Medvecz, Márta, Holló, Péter, Paragh, Gyorgy, Wikonkál, Norbert M, Bozsányi, Szabolcs, Kiss, Norbert
Format: Article
Language:English
Subjects:
Algorithms
Cancer
Decision making
Dermatology
Diagnosis
Epidemiology
Light emitting diodes
Melanoma
Metastases
Oncology, Experimental
Radiation
Skin
Skin cancer
Skin diseases
Tumors
Ultrasonic imaging
Ultrasound
Validation studies
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Summary:Melanoma is the most aggressive form of skin cancer that is known for its metastatic potential and has an increasing incidence worldwide. Breslow thickness, which determines the staging and surgical margin of the tumor, is unavailable at initial diagnosis. Novel imaging techniques for assessing Breslow thickness lack comparative data. This study evaluates optically guided high-frequency ultrasound (OG-HFUS) and multispectral imaging (MSI) for preoperative estimation of Breslow thickness and staging. We enrolled 101 patients with histologically confirmed primary melanoma and categorized them based on tumor thickness. Optically guided 33 MHz HFUS and MSI were utilized for the assessment. Our MSI-based algorithm categorized melanomas into three subgroups with a sensitivity of 62.6%, specificity of 81.3%, and fair agreement (κ = 0.440, CI: 0.298-0.583). In contrast, OG-HFUS demonstrated a sensitivity of 91.8%, specificity of 96.0%, and almost perfect agreement (κ = 0.858, CI: 0.763-0.952). OG-HFUS performed better than MSI in estimating Breslow thickness, emphasizing its potential as a valuable tool for melanoma diagnosis and patient management. OG-HFUS holds promise for enhancing preoperative staging and treatment decision-making in melanoma.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers16010157