Comparative Evaluation of Adipokine Metrics for the Diagnosis of Gestational Diabetes Mellitus

• Published in: International journal of molecular sciences 2023-12, Vol.25 (1), p.175
• Main Authors: Kamiński, Maciej, Mierzyński, Radzisław, Poniedziałek-Czajkowska, Elżbieta, Sadowska, Agata, Sotowski, Maciej, Leszczyńska-Gorzelak, Bożena
• Format: Article
• Language: English
• Subjects: Adipocytes; Adipokines; Adiponectin; Adipose tissues; Amino acids; Apelin; Biological products; Biomarkers; Body fat; Comparative analysis; Development and progression; Diabetes in pregnancy; Diabetes, Gestational - diagnosis; Fatty acids; Female; Gestational diabetes; Glucose; Glycoproteins; Health aspects; Homeostasis; Humans; Hyperglycemia; Insulin resistance; Laboratory animals; Lipocalins; Metabolic disorders; Metabolic syndrome; Obesity; Pathogenesis; Pathophysiology; Peptides; Placenta; Plasma; Pregnancy; Pregnant women; Proteins; Tumor necrosis factor-TNF; Type 2 diabetes; Women; Womens health
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms25010175

Gestational diabetes mellitus (GDM) is one of the most common medical disorders in pregnancy. Adipokines, predominantly secreted by adipose tissue, are involved in numerous metabolic processes. The exact role of adipokines in the pathogenesis of GDM is still not well known, and numerous adipokines have been analysed throughout pregnancy and proposed as biomarkers of GDM. This study aimed to evaluate serum adiponectin, chemerin, lipocalin and apelin levels in GDM and non-GDM women, to assess them as clinically useful biomarkers of the occurrence of GDM and to demonstrate the correlation between the levels of the above adipokines in the blood serum and the increased risk of the development of GDM. The role of these adipokines in the pathogenesis of GDM was also analysed. The statistically significant differences between the levels of adiponectin (7234.6 vs. 9837.5 ng/mL, < 0.0001), chemerin (264.0 vs. 206.7 ng/mL, < 0.0001) and lipocalin (39.5 vs. 19.4 ng/mL, < 0.0001) were observed between pregnant women with GDM and healthy ones. The diagnostic usefulness of the tested adipokines in detecting GDM was also assessed. The research results confirm the hypothesis on the significance of adiponectin, chemerin, lipocalin and apelin in the pathophysiological mechanisms of GDM. We speculate that these adipokines could potentially be established as novel biomarkers for the prediction and early diagnosis of GDM.