Influence of 2 Weeks of Mango Ingestion on Inflammation Resolution after Vigorous Exercise

Mangoes have a unique nutrient profile (carotenoids, polyphenols, sugars, and vitamins) that we hypothesized would mitigate post-exercise inflammation. This study examined the effects of mango ingestion on moderating exercise-induced inflammation in a randomized crossover trial with 22 cyclists. In...

Full description

Saved in:
Bibliographic Details
Published in:Nutrients 2023-12, Vol.16 (1), p.36
Main Authors: Sakaguchi, Camila A, Nieman, David C, Omar, Ashraf M, Strauch, Renee C, Williams, James C, Lila, Mary Ann, Zhang, Qibin
Format: Article
Language:English
Subjects:
Analysis
Animals
Birds
Cross-Over Studies
Cycling
Cyclists
Eating
Females
Fruits
Inflammation
Instrument industry
Mangifera
Metabolites
Nutrition
Oxylipins
Phenols
Physiological aspects
Polyphenols
Water
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Mangoes have a unique nutrient profile (carotenoids, polyphenols, sugars, and vitamins) that we hypothesized would mitigate post-exercise inflammation. This study examined the effects of mango ingestion on moderating exercise-induced inflammation in a randomized crossover trial with 22 cyclists. In random order with trials separated by a 2-week washout period, the cyclists ingested 330 g mango/day with 0.5 L water or 0.5 L of water alone for 2 weeks, followed by a 2.25 h cycling bout challenge. Blood and urine samples were collected pre- and post-2 weeks of supplementation, with additional blood samples collected immediately post-exercise and 1.5-h, 3-h, and 24 h post-exercise. Urine samples were analyzed for targeted mango-related metabolites. The blood samples were analyzed for 67 oxylipins, which are upstream regulators of inflammation and other physiological processes. After 2 weeks of mango ingestion, three targeted urine mango-related phenolic metabolites were significantly elevated compared to water alone (interaction effects, ≤ 0.003). Significant post-exercise increases were measured for 49 oxylipins, but various subgroup analyses showed no differences in the pattern of change between trials (all interaction effects, > 0.150). The 2.25 h cycling bouts induced significant inflammation, but no countermeasure effect was found after 2 weeks of mango ingestion despite the elevation of mango gut-derived phenolic metabolites.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu16010036