No Increase in Acute or Late Radiation Toxicities in Patients With Ehlers-Danlos Syndrome Receiving Adjuvant Breast Radiation Therapy: A Report of Four Cases With Extended Follow-Up

Ehlers-Danlos syndrome (EDS) consists of a heterogeneous group of congenital collagen formation disorders characterised by skin hyperextensibility, atrophic scarring, and generalized joint hypermobility. Collagen vascular disorders have been implicated in increased incidence and severity of radiatio...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2023-12, Vol.15 (12), p.e50346
Main Authors: Hsieh, Michael T, Amalaseelan, Julan, Mohd Tahir, Abdul Rahim, Le, Tue, Shakespeare, Thomas P
Format: Article
Language:English
Subjects:
Aneurysms
Biopsy
Brain research
Breast cancer
Cancer therapies
Case reports
Classification
Collagen
Connective tissue diseases
Dermatitis
Genetics
Lumpectomy
Lymphatic system
Mastectomy
Oncology
Patients
Pericarditis
Radiation Oncology
Radiation therapy
Toxicity
Vein & artery diseases
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Summary:Ehlers-Danlos syndrome (EDS) consists of a heterogeneous group of congenital collagen formation disorders characterised by skin hyperextensibility, atrophic scarring, and generalized joint hypermobility. Collagen vascular disorders have been implicated in increased incidence and severity of radiation toxicities; however, there are limited reports on the safety of radiation therapy with EDS. We identified all patients with EDS who received adjuvant conventional and hypofractionated breast radiation therapy at our institution and reviewed patient, treatment, and toxicity characteristics. Four patients were identified with a median follow-up of 13.2 months. Acute toxicities were limited to grade 1 dermatitis in all four patients. No late toxicities were seen. In this report, radiation therapy to the breast with conventional and hypofractionated regimens resulted in no significant acute or late toxicity.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.50346