Differences in Pleural Fluid Amylase Levels in Patients with Malignant Pleural Effusion Based on Cancer Type, Histologic Type, and Epidermal Growth Factor Receptor Mutations

Objective High pleural amylase levels have been reported in patients with malignant pleural effusion; however, the characteristics of this association are uncertain. Therefore, this study investigated the factors, such as cancer type and oncogenic drivers, related to pleural amylase levels in patien...

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Published in:Internal Medicine 2023/12/15, Vol.62(24), pp.3601-3607
Main Authors: Shimoda, Masafumi, Tanaka, Yoshiaki, Morimoto, Kozo, Yoshimori, Kozo, Ohta, Ken
Format: Article
Language:English
Subjects:
Adenocarcinoma
Adenocarcinoma - pathology
Adenocarcinoma of Lung - complications
amylase
Amylases
Cancer
EGFR
Epidermal growth factor
Epidermal growth factor receptors
ErbB Receptors - genetics
Humans
Internal medicine
Lung cancer
Lung carcinoma
Lung Neoplasms - complications
Lung Neoplasms - genetics
malignant pleural effusion
Medical prognosis
Mesothelioma
Metastases
Mutation
Original
Pleural effusion
Pleural Effusion - complications
Pleural Effusion, Malignant - genetics
Pleural Effusion, Malignant - pathology
Pleural fluid
Retrospective Studies
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Summary:Objective High pleural amylase levels have been reported in patients with malignant pleural effusion; however, the characteristics of this association are uncertain. Therefore, this study investigated the factors, such as cancer type and oncogenic drivers, related to pleural amylase levels in patients with malignant pleural effusion. Methods We retrospectively collected the data of 362 cancer patients [lung adenocarcinoma (n=256), lung squamous carcinoma (n=12), small-cell lung carcinoma (n=32), other lung cancers (n=5), mesothelioma (n=31), and metastatic cancer (n=26)] with malignant pleural effusion at Fukujuji Hospital from January 2012 to October 2022. Pleural amylase levels were compared. Results Pleural amylase levels were significantly higher in patients with lung adenocarcinoma [median 58.6 IU/L (interquartile range (IQR) 33.8-139.3)] than in those with small-cell lung carcinoma [median 37.2 IU/L (IQR 26.3-63.7), p=0.012]. The median pleural amylase level was higher in patients with lung adenocarcinoma than in those with other cancer or histologic types, although the difference was not significant. Pleural amylase levels were higher in epidermal growth factor receptor (EGFR) mutation-positive patients than in EGFR mutation-negative patients [median 95.8 IU/L (IQR 52.7-246.5) vs. median 51.2 IU/L (IQR 27.8-96.9), p
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.1804-23