Prospects of formamide as nitrogen source in biotechnological production processes

This review presents an analysis of formamide, focussing on its occurrence in nature, its functional roles, and its promising applications in the context of the bioeconomy. We discuss the utilization of formamide as an innovative nitrogen source achieved through metabolic engineering. These approach...

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Bibliographic Details
Published in:Applied microbiology and biotechnology 2024-12, Vol.108 (1), p.105-105, Article 105
Main Authors: Schwardmann, Lynn S., Benninghaus, Leonie, Lindner, Steffen N., Wendisch, Volker F.
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biotechnology
Carbon
Carbon dioxide
Carbon sources
Contamination
Fermentation
Formamidase
Formamides
Industrial applications
Life Sciences
Metabolic engineering
Microbial Genetics and Genomics
Microbiology
Mini-Review
Nitrogen
Nitrogen Compounds
Reviews
Substrates
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Summary:This review presents an analysis of formamide, focussing on its occurrence in nature, its functional roles, and its promising applications in the context of the bioeconomy. We discuss the utilization of formamide as an innovative nitrogen source achieved through metabolic engineering. These approaches underscore formamide’s potential in supporting growth and production in biotechnological processes. Furthermore, our review illuminates formamide’s role as a nitrogen source capable of safeguarding cultivation systems against contamination in non-sterile conditions. This attribute adds an extra layer of practicality to its application, rendering it an attractive candidate for sustainable and resilient industrial practices. Additionally, the article unveils the versatility of formamide as a potential carbon source that could be combined with formate or CO 2 assimilation pathways. However, its attributes, i.e., enriched nitrogen content and comparatively limited energy content, led to conclude that formamide is more suitable as a co-substrate and that its use as a sole source of carbon for biomass and bio-production is limited. Through our exploration of formamide’s properties and its applications, this review underscores the significance of formamide as valuable resource for a large spectrum of industrial applications. Key points • Formidases enable access to formamide as source of nitrogen, carbon, and energy • The formamide/formamidase system supports non-sterile fermentation • The nitrogen source formamide supports production of nitrogenous compounds
ISSN:0175-7598
1432-0614
DOI:10.1007/s00253-023-12962-x