Clinical outcomes and prognostic factors in triple-negative invasive lobular carcinoma of the breast

Purpose Triple-negative invasive lobular carcinoma (TN-ILC) of breast cancer is a rare disease and the clinical outcomes and prognostic factors are not well-defined. Methods Women with stage I–III TN-ILC or triple-negative invasive ductal carcinoma (TN-IDC) of the breast undergoing mastectomy or bre...

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Published in:Breast cancer research and treatment 2023-07, Vol.200 (2), p.217-224
Main Authors: Joshi, Utsav, Budhathoki, Pravash, Gaire, Suman, Yadav, Sumeet K., Shah, Anish, Adhikari, Anurag, Choong, Grace, Couzi, Rima, Giridhar, Karthik V., Leon-Ferre, Roberto A., Boughey, Judy C., Hieken, Tina J., Mutter, Robert, Ruddy, Kathryn J., Haddad, Tufia C., Goetz, Matthew P., Couch, Fergus J., Yadav, Siddhartha
Format: Article
Language:English
Subjects:
Aged
Breast cancer
Breast carcinoma
Breast Neoplasms - pathology
Cancer research
Carcinoma, Ductal, Breast - pathology
Carcinoma, Lobular - pathology
Chemotherapy
Clinical outcomes
Diagnosis
Epidemiology
Female
Humans
Invasiveness
Mastectomy
Medical prognosis
Medicine
Medicine & Public Health
Multivariate analysis
Oncology
Prognosis
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Summary:Purpose Triple-negative invasive lobular carcinoma (TN-ILC) of breast cancer is a rare disease and the clinical outcomes and prognostic factors are not well-defined. Methods Women with stage I–III TN-ILC or triple-negative invasive ductal carcinoma (TN-IDC) of the breast undergoing mastectomy or breast-conserving surgery between 2010 and 2018 in the National Cancer Database were included. Kaplan–Meier curves and multivariate Cox proportional hazard regression were used to compare overall survival (OS) and evaluate prognostic factors. Multivariate logistic regression was performed to analyze the factors associated with pathological response to neoadjuvant chemotherapy. Results The median age at diagnosis for women with TN-ILC was 67 years compared to 58 years in TN-IDC ( p  
ISSN:0167-6806
1573-7217
DOI:10.1007/s10549-023-06959-3